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VSV

  • Open Access
    Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State
    Virus-Cell Interactions
    Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State

    Interferons are important antiviral cytokines that work by inducing hundreds of host genes whose products inhibit the replication of many viruses. While the antiviral activity of interferon has long been known, the identities and mechanisms of action of most interferon-induced antiviral proteins remain to be discovered. We identified gene products that are important for the antiviral activity of interferon against vesicular stomatitis...

    Tonya Kueck, Louis-Marie Bloyet, Elena Cassella, Trinity Zang, Fabian Schmidt, Vesna Brusic, Gergely Tekes, Owen Pornillos, Sean P. J. Whelan, Paul D. Bieniasz
  • SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis
    Virus-Cell Interactions
    SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis

    The use of nonpathogenic viruses to target and kill cancer cells is a promising strategy in cancer therapy. However, many types of human cancer are resistant to the oncolytic (cancer-killing) effects of virotherapy. In this study, we identify a host cellular protein, SIRT1, that contributes to the sensitivity of prostate cancer cells to infection by a prototypical oncolytic virus. Knockout of SIRT1 activity increases the sensitivity of...

    Michela Muscolini, Luciano Castiello, Enrico Palermo, Alessandra Zevini, Matteo Ferrari, David Olagnier, John Hiscott
  • Open Access
    Characterization of Antibody Interactions with the G Protein of Vesicular Stomatitis Virus Indiana Strain and Other Vesiculovirus G Proteins
    Vaccines and Antiviral Agents
    Characterization of Antibody Interactions with the G Protein of Vesicular Stomatitis Virus Indiana Strain and Other Vesiculovirus G Proteins

    VSVind.G is currently regarded as the gold-standard envelope glycoprotein to pseudotype lentiviral vectors. However, recently other G proteins derived from vesiculoviruses have been proposed as alternative envelopes. Here, we investigated two commercially available anti-VSVind.G monoclonal antibodies for their ability to cross-react with other vesiculovirus G proteins, identified the epitopes they recognize, and explored their...

    Altar M. Munis, Maha Tijani, Mark Hassall, Giada Mattiuzzo, Mary K. Collins, Yasuhiro Takeuchi
  • Virus-Cell Interactions | Spotlight
    Secretome Screening Reveals Fibroblast Growth Factors as Novel Inhibitors of Viral Replication

    Viruses infect human cells in order to replicate, while human cells aim to resist infection. Several cellular antiviral programs have therefore evolved to resist infection. Knowledge of these programs is essential for the design of antiviral therapeutics in the future. The induction of antiviral programs is often initiated by secreted proteins, such as interferons. We hypothesized that other secreted proteins may also promote resistance...

    Saskia D. van Asten, Matthijs Raaben, Benjamin Nota, Robbert M. Spaapen
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