virulence factors
Pathogenesis and ImmunityWhat a Difference a Gene Makes: Identification of Virulence Factors of Cowpox VirusWith the cessation of vaccination against smallpox and its assumed cross-protectivity against other OPV infections, waning immunity could open up new niches for related poxviruses. Therefore, the identification of virulence mechanisms in CPXV is of general interest. Here, we aimed to identify virulence markers in an experimental rodent CPXV infection model using bacterial artificial chromosome (BAC)-based virus recombineering. We...
Pathogenesis and Immunity | SpotlightNovel Function of Bluetongue Virus NS3 Protein in Regulation of the MAPK/ERK Signaling PathwayBluetongue virus (BTV) is responsible of the arthropod-borne disease bluetongue (BT) transmitted to ruminants by blood-feeding midges. In this report, we found that BTV, through its nonstructural protein NS3 (BTV-NS3), interacts with BRAF, a key component of the MAPK/ERK pathway. In response to growth factors, this pathway promotes cell survival and increases protein translation. We showed that BTV-NS3 enhances the MAPK/ERK pathway, and...
- Virus-Cell InteractionsUnexpected Functional Divergence of Bat Influenza Virus NS1 Proteins
- Virus-Cell InteractionsBaculovirus Per Os Infectivity Factors Form a Complex on the Surface of Occlusion-Derived Virus