Vif
Virus-Cell InteractionsFunctional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational ModelingA critical function of HIV-1 Vif is to counteract the family of APOBEC3 innate immune proteins. It is also widely accepted that Vif induces G2/M cell cycle arrest in several different cell types. Recently, it has been shown that Vif degrades multiple PPP2R5 phosphoregulators to induce the G2/M arrest phenotype. Here, computational approaches are used to test a structural model of the Vif/PPP2R5 complex. In addition...
Virus-Cell InteractionsInhibition of Vif-Mediated Degradation of APOBEC3G through Competitive Binding of Core-Binding Factor BetaOf all the accessory proteins encoded by HIV-1 and other primate lentiviruses, Vif has arguably the strongest potential as a target for antiviral therapy. This conclusion is based on the observation that replication of HIV-1 in vivo is critically dependent on Vif. Thus, inhibiting the function of Vif via small-molecule inhibitors or other approaches has significant therapeutic potential. We previously identified dominant-...
- Virus-Cell InteractionsHIV-1 Vif's Capacity To Manipulate the Cell Cycle Is Species Specific
- Virus-Cell InteractionsThe Structural Interface between HIV-1 Vif and Human APOBEC3H