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Vif

  • Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling
    Virus-Cell Interactions
    Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling

    A critical function of HIV-1 Vif is to counteract the family of APOBEC3 innate immune proteins. It is also widely accepted that Vif induces G2/M cell cycle arrest in several different cell types. Recently, it has been shown that Vif degrades multiple PPP2R5 phosphoregulators to induce the G2/M arrest phenotype. Here, computational approaches are used to test a structural model of the Vif/PPP2R5 complex. In addition...

    Daniel J. Salamango, Jennifer L. McCann, Özlem Demir, Jordan T. Becker, Jiayi Wang, Jairam R. Lingappa, Nuri A. Temiz, William L. Brown, Rommie E. Amaro, Reuben S. Harris
  • Inhibition of Vif-Mediated Degradation of APOBEC3G through Competitive Binding of Core-Binding Factor Beta
    Virus-Cell Interactions
    Inhibition of Vif-Mediated Degradation of APOBEC3G through Competitive Binding of Core-Binding Factor Beta

    Of all the accessory proteins encoded by HIV-1 and other primate lentiviruses, Vif has arguably the strongest potential as a target for antiviral therapy. This conclusion is based on the observation that replication of HIV-1 in vivo is critically dependent on Vif. Thus, inhibiting the function of Vif via small-molecule inhibitors or other approaches has significant therapeutic potential. We previously identified dominant-...

    Eri Miyagi, Sarah Welbourn, Sayaka Sukegawa, Helena Fabryova, Sandra Kao, Klaus Strebel
  • Virus-Cell Interactions
    Simian Immunodeficiency Virus Vif and Human APOBEC3B Interactions Resemble Those between HIV-1 Vif and Human APOBEC3G
    Jiayi Wang, Nadine M. Shaban, Allison M. Land, William L. Brown, Reuben S. Harris
  • Virus-Cell Interactions
    HIV-1 Vif's Capacity To Manipulate the Cell Cycle Is Species Specific
    Edward L. Evans, Jordan T. Becker, Stephanie L. Fricke, Kishan Patel, Nathan M. Sherer
  • Virus-Cell Interactions
    Identification of a Conserved Interface of Human Immunodeficiency Virus Type 1 and Feline Immunodeficiency Virus Vifs with Cullin 5
    Qinyong Gu, Zeli Zhang, Christoph G. W. Gertzen, Dieter Häussinger, Holger Gohlke, Carsten Münk
  • Open Access
    Virus-Cell Interactions
    Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3
    Rokusuke Yoshikawa, Junko S. Takeuchi, Eri Yamada, Yusuke Nakano, Naoko Misawa, Yuichi Kimura, Fengrong Ren, Takayuki Miyazawa, Yoshio Koyanagi, Kei Sato
  • Virus-Cell Interactions
    The Structural Interface between HIV-1 Vif and Human APOBEC3H
    Marcel Ooms, Michael Letko, Viviana Simon
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