unfolded protein response
Structure and AssemblyN-Linked Glycosylation Plays an Important Role in Budding of Neuraminidase Protein and Virulence of Influenza VirusesNA is a highly glycosylated protein. Nevertheless, how the NLG affects the function of NA protein remains largely unclear.
Genome Replication and Regulation of Viral Gene ExpressionPharmacologic Activation of Lytic Epstein-Barr Virus Gene Expression without Virion ProductionEpstein-Barr virus is associated with many different cancers. In these cancers the viral genome is predominantly latent; i.e., most viral genes are not expressed, most viral proteins are not synthesized, and new virions are not produced. Some strategies for treating these cancers involve activation of lytic viral gene expression. We identify an antibacterial antibiotic, clofoctol, that is an activator of EBV lytic RNA and protein...
Cellular Response to InfectionThe Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein ResponseThe unfolded protein response (UPR) is an ancient cellular response to ER stress that is of broad importance to viruses. Certain consequences of the UPR, including mRNA degradation and translational shutoff, would presumably be disadvantageous to viruses, while other attributes of the UPR, such as ER expansion and upregulation of protein folding chaperones, might enhance viral replication. Although HCMV is estimated to express well over...
- Cellular Response to InfectionThe PERK Arm of the Unfolded Protein Response Negatively Regulates Transmissible Gastroenteritis Virus Replication by Suppressing Protein Translation and Promoting Type I Interferon Production
The induction of ER stress is a common outcome in cells infected with coronaviruses. The UPR initiated by ER stress is actively involved in viral replication and modulates the host innate responses to the invading viruses, but these underlying mechanisms remain incompletely understood. We show here that infection with the alphacoronavirus TGEV elicited ER stress in vitro and in vivo, and the UPR PERK-eIF2α branch was...
- Virus-Cell InteractionsDeficiency of the IRE1α-Autophagy Axis Enhances the Antitumor Effects of the Oncolytic Virus M1
- Virus-Cell Interactions | SpotlightZika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response