ubiquitin
Virus-Cell InteractionsVAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus InfectionWNV is a mosquito-borne flavivirus that poses a threat to human health across large discontinuous areas throughout the world. Infection with WNV results in febrile illness, which can progress to severe neurological disease. Currently, there are no approved treatment options to control WNV infection. Understanding the cellular immune responses that regulate viral replication is important in diversifying the resources available to control...
Virus-Cell InteractionsRegulation of the Ebola Virus VP24 Protein by SUMOThe Ebola virus VP24 protein plays a critical role in escape of the virus from the host innate immune response. Therefore, deciphering the molecular mechanisms modulating VP24 activity may be useful to identify potential targets amenable to therapeutics. Here, we identify the cellular proteins USP7, SUMO, and ubiquitin as novel interactors and regulators of VP24. These interactions may represent novel potential targets to design new...
- Virus-Cell InteractionsTRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein
- Virus-Cell InteractionsDeubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases