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ubiquitin

  • VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection
    Virus-Cell Interactions
    VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection

    WNV is a mosquito-borne flavivirus that poses a threat to human health across large discontinuous areas throughout the world. Infection with WNV results in febrile illness, which can progress to severe neurological disease. Currently, there are no approved treatment options to control WNV infection. Understanding the cellular immune responses that regulate viral replication is important in diversifying the resources available to control...

    Sarah van Tol, Colm Atkins, Preeti Bharaj, Kendra N. Johnson, Adam Hage, Alexander N. Freiberg, Ricardo Rajsbaum
  • Regulation of the Ebola Virus VP24 Protein by SUMO
    Virus-Cell Interactions
    Regulation of the Ebola Virus VP24 Protein by SUMO

    The Ebola virus VP24 protein plays a critical role in escape of the virus from the host innate immune response. Therefore, deciphering the molecular mechanisms modulating VP24 activity may be useful to identify potential targets amenable to therapeutics. Here, we identify the cellular proteins USP7, SUMO, and ubiquitin as novel interactors and regulators of VP24. These interactions may represent novel potential targets to design new...

    Santiago Vidal, Ahmed El Motiam, Rocío Seoane, Viktorija Preitakaite, Yanis Hichem Bouzaher, Sergio Gómez-Medina, Carmen San Martín, Dolores Rodríguez, María Teresa Rejas, Maite Baz-Martínez, Rosa Barrio, James D. Sutherland, Manuel S. Rodríguez, César Muñoz-Fontela, Carmen Rivas
  • Virus-Cell Interactions
    E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression
    Sarah Müncheberg, Ron T. Hay, Wing H. Ip, Tina Meyer, Christina Weiß, Jara Brenke, Sawinee Masser, Kamyar Hadian, Thomas Dobner, Sabrina Schreiner
  • Virus-Cell Interactions
    TRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein
    Xiaojiao Zheng, Xinlu Wang, Fan Tu, Qin Wang, Zusen Fan, Guangxia Gao
  • Virus-Cell Interactions
    The Linear Ubiquitin Assembly Complex Modulates Latent Membrane Protein 1 Activation of NF-κB and Interferon Regulatory Factor 7
    Ling Wang, Yujia Wang, Juan Zhao, Junping Ren, Kenton H. Hall, Jonathan P. Moorman, Zhi Q. Yao, Shunbin Ning
  • Virus-Cell Interactions
    Porcine Reproductive and Respiratory Syndrome Virus nsp1α Inhibits NF-κB Activation by Targeting the Linear Ubiquitin Chain Assembly Complex
    Huiyuan Jing, Liurong Fang, Zhen Ding, Dang Wang, Wenqi Hao, Li Gao, Wenting Ke, Huanchun Chen, Shaobo Xiao
  • Virus-Cell Interactions
    Inhibition of the Ubiquitin-Proteasome System Affects Influenza A Virus Infection at a Postfusion Step
    Ivy Widjaja, Erik de Vries, Donna M. Tscherne, Adolfo García-Sastre, Peter J. M. Rottier, Cornelis A. M. de Haan
  • Virus-Cell Interactions
    The Cysteine Protease Domain of Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Possesses Deubiquitinating and Interferon Antagonism Functions
    Zhi Sun, Zhenhai Chen, Steven R. Lawson, Ying Fang
  • Virus-Cell Interactions
    The Ubiquitin-Proteasome System Plays an Important Role during Various Stages of the Coronavirus Infection Cycle
    Matthijs Raaben, Clara C. Posthuma, Monique H. Verheije, Eddie G. te Lintelo, Marjolein Kikkert, Jan W. Drijfhout, Eric J. Snijder, Peter J. M. Rottier, Cornelis A. M. de Haan
  • Virus-Cell Interactions
    Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases
    Mark A. Clementz, Zhongbin Chen, Bridget S. Banach, Yanhua Wang, Li Sun, Kiira Ratia, Yahira M. Baez-Santos, Jie Wang, Jun Takayama, Arun K. Ghosh, Kui Li, Andrew D. Mesecar, Susan C. Baker

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