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tick-borne encephalitis virus

  • Open Access
    Model System for the Formation of Tick-Borne Encephalitis Virus Replication Compartments without Viral RNA Replication
    Virus-Cell Interactions
    Model System for the Formation of Tick-Borne Encephalitis Virus Replication Compartments without Viral RNA Replication

    TBEV infection causes a broad spectrum of symptoms, ranging from mild fever to severe encephalitis. Similar to other flaviviruses, TBEV exploits intracellular membranes to build RCs for viral replication. The viral NS proteins have been suggested to be involved in this process; however, the mechanism of RC formation and the roles of individual NS proteins remain unclear. To study how TBEV induces membrane remodeling, we developed an...

    Wai-Lok Yau, Van Nguyen-Dinh, Elin Larsson, Richard Lindqvist, Anna K. Överby, Richard Lundmark
  • An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice
    Vaccines and Antiviral Agents | Spotlight
    An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice

    Tick-borne encephalitis virus (TBEV) is a pathogen that causes severe human neuroinfections in Europe and Asia and for which there is currently no specific therapy. We have previously found that galidesivir (BCX4430), a broad-spectrum RNA virus inhibitor, which is under clinical development for treatment of Ebola and yellow fever virus infections, has a strong antiviral effect against TBEV. For any antiviral drug, it is important to...

    Ludek Eyer, Antoine Nougairède, Marie Uhlířová, Jean-Sélim Driouich, Darina Zouharová, James J. Valdés, Jan Haviernik, Ernest A. Gould, Erik De Clercq, Xavier de Lamballerie, Daniel Ruzek
  • Open Access
    Cellular Response to Infection | Spotlight
    Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid Particles
    Kirstin Vonderstein, Emma Nilsson, Philipp Hubel, Larsård Nygård Skalman, Arunkumar Upadhyay, Jenny Pasto, Andreas Pichlmair, Richard Lundmark, Anna K. Överby
  • Vaccines and Antiviral Agents | Spotlight
    Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness
    Ludek Eyer, Hirofumi Kondo, Darina Zouharova, Minato Hirano, James J. Valdés, Memi Muto, Tomas Kastl, Shintaro Kobayashi, Jan Haviernik, Manabu Igarashi, Hiroaki Kariwa, Marketa Vaculovicova, Jiri Cerny, Rene Kizek, Andrea Kröger, Stefan Lienenklaus, Milan Dejmek, Radim Nencka, Martin Palus, Jiri Salat, Erik De Clercq, Kentaro Yoshii, Daniel Ruzek
  • Minireview
    The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon Signaling
    Sonja M. Best
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