simian virus 40
Virus-Cell Interactions | SpotlightUbqln4 Facilitates Endoplasmic Reticulum-to-Cytosol Escape of a Nonenveloped Virus during InfectionHow a nonenveloped virus escapes from a host membrane to promote infection remains enigmatic. In the case of the nonenveloped polyomavirus SV40, penetration of the ER membrane to reach the cytosol is a decisive virus infection step. In this study, we found a new host factor called Ubqln4 that facilitates escape of SV40 from the ER into the cytosol, thereby providing a path for the virus to enter the nucleus to cause infection.
...
Virus-Cell Interactions | SpotlightContribution of DNA Replication to the FAM111A-Mediated Simian Virus 40 Host Range PhenotypeSV40 has served as a powerful tool for understanding fundamental viral and cellular processes; however, despite extensive study, the SV40 HR mutant phenotype remains poorly understood. Mutations in the C terminus of large T antigen that disrupt binding to the host protein FAM111A render SV40 HR viruses unable to replicate in restrictive cell types. Our work reveals a defect of HR mutant viruses in the formation of viral replication...
GemThe RNA Epitranscriptome of DNA VirusesRNA modifications have generated much interest in the virology field, as recent works have shown that many viruses harbor these marks and modify cellular marks. The most abundant mRNA modification in eukaryotic cells, N6-methyladenosine (m6A), has been examined extensively at the genome-wide scale in both cellular and viral contexts.
- Virus-Cell Interactions | SpotlightSGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum
- Virus-Cell InteractionsSimian Virus 40 Activates ATR-Δp53 Signaling To Override Cell Cycle and DNA Replication Control
- Virus-Cell InteractionsMultiple DNA Damage Signaling and Repair Pathways Deregulated by Simian Virus 40 Large T Antigen
- Transformation and OncogenesisWild-Type p53 Enhances Efficiency of Simian Virus 40 Large-T-Antigen-Induced Cellular Transformation