S fragment
Pathogenesis and Immunity | SpotlightGenetic Determinants of Altered Virulence of Type O Foot-and-Mouth Disease VirusFMD is probably the most important livestock disease in the world due to the severe economic consequences caused. The alteration of several viral genes may give the virus selective advantage to maintain its prevalence in nature. Here, we identified that a 70-nucleotide deletion in the S fragment combined with a single leucine insertion in the leader protein (Lpro) is a novel determinant of restricted growth on bovine cells,...