RNA splicing
Genome Replication and Regulation of Viral Gene Expression | SpotlightControl of Archetype BK Polyomavirus MicroRNA ExpressionThe BK polyomavirus (BKPyV) miRNA plays an important role in regulating viral large-T-antigen expression and limiting the replication of archetype BKPyV, suggesting that the miRNA regulates BKPyV persistence. However, how miRNA expression is regulated is poorly understood. Here, we present evidence that the miRNA is expressed from an intron that is generated by RNA polymerase II transcribing the circular viral genome more than once. We...
Virus-Cell InteractionsIntegrated Assessment of Viral Transcription, Antigen Presentation, and CD8+ T Cell Function Reveals Multiple Limitations of Class I-Selective Histone Deacetylase Inhibitors during HIV-1 Latency ReversalAntiretroviral (ARV) drug regimens suppress HIV-1 replication but are unable to cure infection. This leaves people living with HIV-1 burdened by a lifelong commitment to expensive daily medication. Furthermore, it has become clear that ARV therapy does not fully restore health, leaving individuals at elevated risk for cardiovascular disease, certain types of cancers, and neurocognitive disorders, as well as leaving them exposed to...
GemPicornaviruses and RNA Metabolism: Local and Global Effects of InfectionDue to the limiting coding capacity for members of the Picornaviridae family of positive-strand RNA viruses, their successful replication cycles require complex interactions with host cell functions.
Genome Replication and Regulation of Viral Gene ExpressionSplicing-Dependent Subcellular Targeting of Borna Disease Virus Nucleoprotein IsoformsBorna disease virus (BoDV) is a highly neurotropic RNA virus that belongs to the orthobornavirus genus. A zoonotic orthobornavirus that is genetically related to BoDV has recently been identified in squirrels, thus increasing the importance of understanding the replication and pathogenesis of orthobornaviruses. BoDV replicates in the nucleus and uses alternative mRNA splicing to express viral proteins. However, it is unknown whether the...
- Genome Replication and Regulation of Viral Gene ExpressionThe HIV-1 Tat Protein Enhances Splicing at the Major Splice Donor Site
- Genome Replication and Regulation of Viral Gene ExpressionCharacterization of cis-Acting RNA Elements of Zika Virus by Using a Self-Splicing Ribozyme-Dependent Infectious Clone
- Genome Replication and Regulation of Viral Gene ExpressionDifferential Requirement of Human Cytomegalovirus UL112-113 Protein Isoforms for Viral Replication
- Genome Replication and Regulation of Viral Gene ExpressionKaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic Replication
- Genome Replication and Regulation of Viral Gene Expression | SpotlightMinute Virus of Canines NP1 Protein Governs the Expression of a Subset of Essential Nonstructural Proteins via Its Role in RNA Processing
- Genome Replication and Regulation of Viral Gene Expression | SpotlightCharacterizing HIV-1 Splicing by Using Next-Generation Sequencing