ribavirin
Genome Replication and Regulation of Viral Gene ExpressionAn Extended Primer Grip of Picornavirus Polymerase Facilitates Sexual RNA Replication MechanismsPicornaviruses have both asexual and sexual RNA replication mechanisms. Sexual RNA replication shapes picornavirus species groups, contributes to the emergence of vaccine-derived polioviruses, and counteracts error catastrophe. Can viruses distinguish between homologous and nonhomologous partners during sexual RNA replication? We implicate an extended primer grip of the viral polymerase in sexual RNA replication mechanisms. By sensing...
Genome Replication and Regulation of Viral Gene ExpressionPicornavirus RNA Recombination Counteracts Error CatastrophePositive-strand RNA viruses produce vast amounts of progeny in very short periods of time via template-dependent RNA replication mechanisms. Template-dependent RNA replication, while efficient, can be disadvantageous due to error-prone viral polymerases. The accumulation of mutations in viral RNA genomes leads to error catastrophe. In this study, we substantiate long-held theories regarding the advantages and disadvantages of asexual...
Vaccines and Antiviral AgentsContribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal MutagenesisThe nuclear localization signal (NLS) of the foot-and-mouth disease virus (FMDV) polymerase includes residues that modulate the sensitivity to mutagenic agents. Here we have described a viable NLS mutant with an amino acid replacement that facilitates virus extinction by ribavirin. The corresponding polymerase shows increased incorporation of ribavirin triphosphate and local structural modifications that implicate the template entry...
- Pathogenesis and ImmunityA Neonatal Murine Model of Coxsackievirus A6 Infection for Evaluation of Antiviral and Vaccine Efficacy
- Genome Replication and Regulation of Viral Gene ExpressionAn In Vitro RNA Synthesis Assay for Rabies Virus Defines Ribonucleoprotein Interactions Critical for Polymerase Activity
- Genetic Diversity and EvolutionEffect of Ribavirin on the Mutation Rate and Spectrum of Hepatitis C Virus In Vivo
