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ribavirin

  • An Extended Primer Grip of Picornavirus Polymerase Facilitates Sexual RNA Replication Mechanisms
    Genome Replication and Regulation of Viral Gene Expression
    An Extended Primer Grip of Picornavirus Polymerase Facilitates Sexual RNA Replication Mechanisms

    Picornaviruses have both asexual and sexual RNA replication mechanisms. Sexual RNA replication shapes picornavirus species groups, contributes to the emergence of vaccine-derived polioviruses, and counteracts error catastrophe. Can viruses distinguish between homologous and nonhomologous partners during sexual RNA replication? We implicate an extended primer grip of the viral polymerase in sexual RNA replication mechanisms. By sensing...

    Brian J. Kempf, Colleen L. Watkins, Olve B. Peersen, David J. Barton
  • Picornavirus RNA Recombination Counteracts Error Catastrophe
    Genome Replication and Regulation of Viral Gene Expression
    Picornavirus RNA Recombination Counteracts Error Catastrophe

    Positive-strand RNA viruses produce vast amounts of progeny in very short periods of time via template-dependent RNA replication mechanisms. Template-dependent RNA replication, while efficient, can be disadvantageous due to error-prone viral polymerases. The accumulation of mutations in viral RNA genomes leads to error catastrophe. In this study, we substantiate long-held theories regarding the advantages and disadvantages of asexual...

    Brian J. Kempf, Colleen L. Watkins, Olve B. Peersen, David J. Barton
  • Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis
    Vaccines and Antiviral Agents
    Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis

    The nuclear localization signal (NLS) of the foot-and-mouth disease virus (FMDV) polymerase includes residues that modulate the sensitivity to mutagenic agents. Here we have described a viable NLS mutant with an amino acid replacement that facilitates virus extinction by ribavirin. The corresponding polymerase shows increased incorporation of ribavirin triphosphate and local structural modifications that implicate the template entry...

    Ignacio de la Higuera, Cristina Ferrer-Orta, Elena Moreno, Ana Isabel de Ávila, María Eugenia Soria, Kamalendra Singh, Flavia Caridi, Francisco Sobrino, Stefan G. Sarafianos, Celia Perales, Nuria Verdaguer, Esteban Domingo
  • Open Access
    Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus
    Virus-Cell Interactions
    Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus
    Kristina Nyström, Paulina H. Wanrooij, Jesper Waldenström, Ludmila Adamek, Sofia Brunet, Joanna Said, Staffan Nilsson, Megan Wind-Rotolo, Kristoffer Hellstrand, Helene Norder, Ka-Wei Tang, Martin Lagging
  • Pathogenesis and Immunity
    A Neonatal Murine Model of Coxsackievirus A6 Infection for Evaluation of Antiviral and Vaccine Efficacy
    Zhenjie Zhang, Zhaopeng Dong, Qingjuan Wei, Michael J. Carr, Juan Li, Shujun Ding, Yigang Tong, Dong Li, Weifeng Shi
  • Genome Replication and Regulation of Viral Gene Expression
    An In Vitro RNA Synthesis Assay for Rabies Virus Defines Ribonucleoprotein Interactions Critical for Polymerase Activity
    Benjamin Morin, Bo Liang, Erica Gardner, Robin A. Ross, Sean P. J. Whelan
  • Pathogenesis and Immunity
    A Novel Model of Lethal Hendra Virus Infection in African Green Monkeys and the Effectiveness of Ribavirin Treatment
    Barry Rockx, Katharine N. Bossart, Friederike Feldmann, Joan B. Geisbert, Andrew C. Hickey, Douglas Brining, Julie Callison, David Safronetz, Andrea Marzi, Lisa Kercher, Dan Long, Christopher C. Broder, Heinz Feldmann, Thomas W. Geisbert
  • Structure and Assembly
    Structure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to Ribavirin
    Cristina Ferrer-Orta, Macarena Sierra, Rubén Agudo, Ignacio de la Higuera, Armando Arias, Rosa Pérez-Luque, Cristina Escarmís, Esteban Domingo, Nuria Verdaguer
  • Pathogenesis and Immunity
    High Levels of Chronic Immune Activation in the T-Cell Compartments of Patients Coinfected with Hepatitis C Virus and Human Immunodeficiency Virus Type 1 and on Highly Active Antiretroviral Therapy Are Reverted by Alpha Interferon and Ribavirin Treatment
    Veronica D. Gonzalez, Karolin Falconer, Kim G. Blom, Olle Reichard, Birgitte Mørn, Alex Lund Laursen, Nina Weis, Annette Alaeus, Johan K. Sandberg
  • Genetic Diversity and Evolution
    Effect of Ribavirin on the Mutation Rate and Spectrum of Hepatitis C Virus In Vivo
    José M. Cuevas, Fernando González-Candelas, Andrés Moya, Rafael Sanjuán

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