Reoviridae
Virus-Cell Interactions | SpotlightRotavirus Species B Encodes a Functional Fusion-Associated Small Transmembrane ProteinWhile species A rotavirus is commonly associated with diarrheal disease in young children, species B rotavirus has caused sporadic outbreaks of adult diarrheal disease. A major genetic difference between species A and B rotaviruses is the NSP1 gene, which encodes two proteins for species B rotavirus. We demonstrate that the smaller of these proteins, NSP1-1, can mediate fusion of cultured human cells. Comparison with viral proteins of...
Pathogenesis and Immunity | SpotlightNovel Function of Bluetongue Virus NS3 Protein in Regulation of the MAPK/ERK Signaling PathwayBluetongue virus (BTV) is responsible of the arthropod-borne disease bluetongue (BT) transmitted to ruminants by blood-feeding midges. In this report, we found that BTV, through its nonstructural protein NS3 (BTV-NS3), interacts with BRAF, a key component of the MAPK/ERK pathway. In response to growth factors, this pathway promotes cell survival and increases protein translation. We showed that BTV-NS3 enhances the MAPK/ERK pathway, and...
- Pathogenesis and ImmunityGrass Carp Reovirus VP41 Targets Fish MITA To Abrogate the Interferon Response
- Virus-Cell Interactions | SpotlightViral RNA at Two Stages of Reovirus Infection Is Required for the Induction of Necroptosis
- Structure and Assembly | SpotlightStructural Insights into Reovirus σ1 Interactions with Two Neutralizing Antibodies
- Virus-Cell Interactions | SpotlightDeterminants of Strain-Specific Differences in Efficiency of Reovirus Entry
- Virus-Cell InteractionsMultiple Functions of Rice Dwarf Phytoreovirus Pns10 in Suppressing Systemic RNA Silencing
- Pathogenesis and ImmunityInterferon Regulatory Factor 3 Attenuates Reovirus Myocarditis and Contributes to Viral Clearance