Receptors, CXCR4

Virus-Cell Interactions
Modest Human Immunodeficiency Virus Coreceptor Function of CXCR3 Is Strongly Enhanced by Mimicking the CXCR4 Ligand Binding Pocket in the CXCR3 Receptor
Sigrid Hatse, Dana Huskens, Katrien Princen, Kurt Vermeire, Gary J. Bridger, Erik De Clercq, Mette M. Rosenkilde, Thue W. Schwartz, Dominique Schols
Pathogenesis and Immunity
Increased Neutralization Sensitivity of Recently Emerged CXCR4-Using Human Immunodeficiency Virus Type 1 Strains Compared to Coexisting CCR5-Using Variants from the Same Patient
Evelien M. Bunnik, Esther D. Quakkelaar, Ad C. van Nuenen, Brigitte Boeser-Nunnink, Hanneke Schuitemaker
Virus-Cell Interactions
Expression of Nef Downregulates CXCR4, the Major Coreceptor of Human Immunodeficiency Virus, from the Surfaces of Target Cells and Thereby Enhances Resistance to Superinfection
Stephanie Venzke, Nico Michel, Ina Allespach, Oliver T. Fackler, Oliver T. Keppler
Pathogenesis and Immunity
Naïve T-Cell Depletion Related to Infection by X4 Human Immunodeficiency Virus Type 1 in Poor Immunological Responders to Highly Active Antiretroviral Therapy
Pierre Delobel, Marie-Thérèse Nugeyre, Michelle Cazabat, Karine Sandres-Sauné, Christophe Pasquier, Lise Cuzin, Bruno Marchou, Patrice Massip, Rémi Cheynier, Françoise Barré-Sinoussi, Jacques Izopet, Nicole Israël
Vaccines and Antiviral Agents
Emergence of CXCR4-Using Human Immunodeficiency Virus Type 1 (HIV-1) Variants in a Minority of HIV-1-Infected Patients following Treatment with the CCR5 Antagonist Maraviroc Is from a Pretreatment CXCR4-Using Virus Reservoir
Mike Westby, Marilyn Lewis, Jeannette Whitcomb, Mike Youle, Anton L. Pozniak, Ian T. James, Tim M. Jenkins, Manos Perros, Elna van der Ryst
Genome Replication and Regulation of Viral Gene Expression
Sequential CD134-CXCR4 Interactions in Feline Immunodeficiency Virus (FIV): Soluble CD134 Activates FIV Env for CXCR4-Dependent Entry and Reveals a Cryptic Neutralization Epitope
Aymeric de Parseval, Chris K. Grant, K. Jagannadha Sastry, John H. Elder
Pathogenesis and Immunity
Naïve and Memory Cell Turnover as Drivers of CCR5-to-CXCR4 Tropism Switch in Human Immunodeficiency Virus Type 1: Implications for Therapy
Ruy M. Ribeiro, Mette D. Hazenberg, Alan S. Perelson, Miles P. Davenport
Vaccines and Antiviral Agents
Unique Ligand Binding Sites on CXCR4 Probed by a Chemical Biology Approach: Implications for the Design of Selective Human Immunodeficiency Virus Type 1 Inhibitors
Won-Tak Choi, Shaomin Tian, Chang-Zhi Dong, Santosh Kumar, Dongxiang Liu, Navid Madani, Jing An, Joseph G. Sodroski, Ziwei Huang
Pathogenesis and Immunity
Complex Determinants in Human Immunodeficiency Virus Type 1 Envelope gp120 Mediate CXCR4-Dependent Infection of Macrophages
Guity Ghaffari, Daniel L. Tuttle, Daniel Briggs, Brant R. Burkhardt, Deepa Bhatt, Warren A. Andiman, John W. Sleasman, Maureen M. Goodenow
Virus-Cell Interactions
Distinct Functional Sites for Human Immunodeficiency Virus Type 1 and Stromal Cell-Derived Factor 1α on CXCR4 Transmembrane Helical Domains
Shaomin Tian, Won-Tak Choi, Dongxiang Liu, James Pesavento, Youli Wang, Jing An, Joseph G. Sodroski, Ziwei Huang

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