rabies virus
Pathogenesis and ImmunityInterferon-Inducible GTPase 1 Impedes the Dimerization of Rabies Virus Phosphoprotein and Restricts Viral ReplicationInterferon and its downstream products, ISGs, are essential in defending against pathogen invasion. One of the ISGs, IIGP1, has been found to constrain intracellular parasite infection by disrupting their vacuole membranes. However, the role of IIGP1 in limiting viral infection is unclear. In this study, we show that infection with a typical neurotropic virus, RABV, can induce upregulation of IIGP1, which, in turn, suppresses RABV by...
Pathogenesis and ImmunityDual Role of Toll-Like Receptor 7 in the Pathogenesis of Rabies Virus in a Mouse ModelDeveloping targeted treatment for RABV requires understanding the innate immune response to the virus because early virus clearance is essential for preventing the fatality when the infection has progressed to the CNS. Previous studies have revealed that TLR7 is involved in the immune response to RABV. Here, we establish that TLR7 recognizes RABV and facilitates the production of some interferon-stimulated genes. We also demonstrated...
Virus-Cell InteractionsIntegrin β1 Promotes Peripheral Entry by Rabies VirusRabies is a severe zoonotic disease caused by rabies virus (RABV). However, the nature of RABV entry remains unclear, which has hindered the development of therapy for rabies. It is suggested that modulations of RABV glycoprotein and multiple host factors are responsible for RABV invasion. Here, we showed that integrin β1 (ITGB1) directly interacts with RABV glycoprotein, and both proteins are internalized together into host cells....
Vaccines and Antiviral AgentsA Recombinant Rabies Virus Expressing the Marburg Virus Glycoprotein Is Dependent upon Antibody-Mediated Cellular Cytotoxicity for Protection against Marburg Virus Disease in a Murine ModelMarburg virus (MARV) is a virus similar to Ebola virus and also causes a hemorrhagic disease which is highly lethal. In contrast to EBOV, only a few vaccines have been developed against MARV, and researchers do not understand what kind of immune responses are required to protect from MARV. Here we show that antibodies directed against MARV after application of our vaccine protect in an animal system but fail to neutralize the virus in a...
Pathogenesis and Immunity | SpotlightInhibition of MALT1 Decreases Neuroinflammation and Pathogenicity of Virulent Rabies Virus in MiceRabies virus is a neurotropic RNA virus that causes encephalitis and still poses an enormous challenge to animal and public health. Efforts to establish reliable therapeutic strategies have been unsuccessful and are hampered by gaps in the understanding of virus pathogenicity. MALT1 is an intracellular protease that mediates the activation of several innate and adaptive immune cells in response to multiple receptors, and therapeutic...
- Pathogenesis and ImmunityMALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain
- Genome Replication and Regulation of Viral Gene ExpressionMolecular Function Analysis of Rabies Virus RNA Polymerase L Protein by Using an L Gene-Deficient Virus
- Pathogenesis and ImmunityIfit2 Is a Restriction Factor in Rabies Virus Pathogenicity
- Vaccines and Antiviral AgentsOverexpression of Interleukin-7 Extends the Humoral Immune Response Induced by Rabies Vaccination