polyomavirus
Virus-Cell Interactions | SpotlightInfectious Entry of Merkel Cell PolyomavirusMCPyV is the first polyomavirus directly implicated in the development of an aggressive human cancer, Merkel cell carcinoma (MCC). Although MCPyV is constantly shed from healthy skin, the MCC incidence increases among aging and immunocompromised individuals. To date, the events connecting initial MCPyV infection and subsequent transformation still remain elusive. MCPyV differs from other known polyomaviruses concerning its cell tropism...
- Genome Replication and Regulation of Viral Gene ExpressionThe Murine Polyomavirus MicroRNA Locus Is Required To Promote Viruria during the Acute Phase of Infection
MicroRNAs are expressed by diverse viruses, but for only a few is there any understanding of their in vivo function. PyVs can cause serious disease in immunocompromised hosts. Therefore, increased knowledge of how these viruses interact with the immune response is of clinical relevance. Here we show a novel activity for a viral miRNA locus in promoting virus shedding. This work indicates that in addition to any role for the PyV...
- Virus-Cell Interactions | SpotlightDynein Engages and Disassembles Cytosol-Localized Simian Virus 40 To Promote Infection
- Genome Replication and Regulation of Viral Gene ExpressionNovel Human Polyomavirus Noncoding Control Regions Differ in Bidirectional Gene Expression according to Host Cell, Large T-Antigen Expression, and Clinically Occurring Rearrangements
- Virus-Cell InteractionsERK Is a Critical Regulator of JC Polyomavirus Infection
- Transformation and OncogenesisA Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling