poliovirus
Genetic Diversity and Evolution | SpotlightIdentification and Characterization of a Poliovirus Capsid Mutant with Enhanced Thermal StabilityViruses spread by the fecal-oral route need to maintain viability in the environment to ensure transmission. Previous work indicated that bacteria and bacterial surface polysaccharides can stabilize viral particles and enhance transmission. To explore factors that influence viral particle stability, we isolated a mutant poliovirus that is heat resistant. This mutant virus does not require feces for stability at most temperatures but can...
Genetic Diversity and EvolutionInvolvement of a Nonstructural Protein in Poliovirus Capsid AssemblyRNA viruses, including poliovirus, evolve rapidly due to the error-prone nature of the polymerase enzymes involved in genome replication. Fixation of advantageous mutations may require the acquisition of complementary mutations which can act in concert to achieve a favorable phenotype. This study highlights a compensatory role of a nonstructural regulatory protein, 2Apro, for an otherwise lethal mutation of the structural VP1...
- Vaccines and Antiviral AgentsNewcastle Disease Virus-Based Vectored Vaccine against Poliomyelitis
A new, safe, and effective vaccine against poliovirus is urgently needed not only to complete the eradication of the virus but also to be used in the future to prevent possible virus reemergence in a postpolio world. Currently, new formulations of the oral vaccine, as well as improvements to the inactivated vaccine, are being explored. In this study, we designed a viral vector with mucosal tropism that expresses poliovirus capsid...
- Genetic Diversity and Evolution | SpotlightDynamics of Evolution of Poliovirus Neutralizing Antigenic Sites and Other Capsid Functional Domains during a Large and Prolonged Outbreak
- Vaccines and Antiviral AgentsIncreasing Type 1 Poliovirus Capsid Stability by Thermal Selection
- Virus-Cell Interactions | SpotlightCryo-electron Microscopy Structures of Expanded Poliovirus with VHHs Sample the Conformational Repertoire of the Expanded State
