Point Mutation

Virus-Cell Interactions
A Point Mutation in the Rhesus Rotavirus VP4 Protein Generated through a Rotavirus Reverse Genetics System Attenuates Biliary Atresia in the Murine Model
Sujit K. Mohanty, Bryan Donnelly, Phylicia Dupree, Inna Lobeck, Sarah Mowery, Jaroslaw Meller, Monica McNeal, Greg Tiao
Structure and Assembly
A Point Mutation in the N-Terminal Amphipathic Helix α₀ in NS3 Promotes Hepatitis C Virus Assembly by Altering Core Localization to the Endoplasmic Reticulum and Facilitating Virus Budding
Yu Yan, Ying He, Bertrand Boson, Xuesong Wang, François-Loïc Cosset, Jin Zhong
Virus-Cell Interactions
Remarkable Lethal G-to-A Mutations in vif-Proficient HIV-1 Provirus by Individual APOBEC3 Proteins in Humanized Mice
Kei Sato, Taisuke Izumi, Naoko Misawa, Tomoko Kobayashi, Yoshiki Yamashita, Masahide Ohmichi, Mamoru Ito, Akifumi Takaori-Kondo, Yoshio Koyanagi
Genetic Diversity and Evolution
High Variability and Rapid Evolution of a Nanovirus
Ioana Grigoras, Tatiana Timchenko, Ana Grande-Pérez, Lina Katul, Heinrich-Josef Vetten, Bruno Gronenborn
Pathogenesis and Immunity
Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs
Kathleen C. Prins, Sebastien Delpeut, Daisy W. Leung, Olivier Reynard, Valentina A. Volchkova, St. Patrick Reid, Parameshwaran Ramanan, Washington B. Cárdenas, Gaya K. Amarasinghe, Viktor E. Volchkov, Christopher F. Basler
Virus-Cell Interactions
A Single Point Mutation in Nonstructural Protein NS2 of Bovine Viral Diarrhea Virus Results in Temperature-Sensitive Attenuation of Viral Cytopathogenicity
Alexander Pankraz, Simone Preis, Heinz-Jürgen Thiel, Andreas Gallei, Paul Becher
Genome Replication and Regulation of Viral Gene Expression
Mouse Hepatitis Virus Stem-Loop 2 Adopts a uYNMG(U)a-Like Tetraloop Structure That Is Highly Functionally Tolerant of Base Substitutions
Pinghua Liu, Lichun Li, Sarah C. Keane, Dong Yang, Julian L. Leibowitz, David P. Giedroc
Genome Replication and Regulation of Viral Gene Expression
Mutations at Alternative 5′ Splice Sites of M1 mRNA Negatively Affect Influenza A Virus Viability and Growth Rate
Chiayn Chiang, Guang-Wu Chen, Shin-Ru Shih
Genome Replication and Regulation of Viral Gene Expression
Identification of Mutated Cyclization Sequences That Permit Efficient Replication of West Nile Virus Genomes: Use in Safer Propagation of a Novel Vaccine Candidate
Ryosuke Suzuki, Rafik Fayzulin, Ilya Frolov, Peter W. Mason
Pathogenesis and Immunity
A Point Mutation Leading to Hepatitis C Virus Escape from Neutralization by a Monoclonal Antibody to a Conserved Conformational Epitope
Zhen-Yong Keck, Oakley Olson, Meital Gal-Tanamy, Jinming Xia, Arvind H. Patel, Marlène Dreux, Francois-Loïc Cosset, Stanley M. Lemon, Steven K. H. Foung

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