physical interaction
Virus-Cell InteractionsEpstein-Barr Virus Episome Physically Interacts with Active Regions of the Host Genome in Lymphoblastoid CellsEBV is associated with ∼200,000 cancers each year. In vitro, EBV can transform primary human B lymphocytes into immortalized cell lines. EBV-encoded proteins, along with noncoding RNAs and microRNAs, hijack cellular proteins and pathways to control cell growth. EBV nuclear proteins usurp normal transcriptional programs to activate the expression of key oncogenes, including MYC, to provide a proliferation signal. EBV nuclear...