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nonneutralizing antibodies

  • Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation
    Pathogenesis and Immunity
    Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation

    Stabilization of HIV-1 Env state 2A has been shown to sensitize infected cells to ADCC. State 2A can be stabilized by a “cocktail” composed of CD4mc, anti-CoRBS, and anti-cluster A Abs.

    Dani Vézina, Shang Yu Gong, William D. Tolbert, Shilei Ding, Dung Nguyen, Jonathan Richard, Gabrielle Gendron-Lepage, Bruno Melillo, Amos B. Smith, Marzena Pazgier, Andrés Finzi
  • Porcine Reproductive and Respiratory Syndrome Virus Promotes SLA-DR-Mediated Antigen Presentation of Nonstructural Proteins To Evoke a Nonneutralizing Antibody Response <em>In Vivo</em>
    Pathogenesis and Immunity
    Porcine Reproductive and Respiratory Syndrome Virus Promotes SLA-DR-Mediated Antigen Presentation of Nonstructural Proteins To Evoke a Nonneutralizing Antibody Response In Vivo

    PRRSV has haunted the swine industry for over 30 years since its emergence. Besides the limited efficacy of PRRSV modified live vaccines (MLVs) against heterogeneous PRRSV isolates, rapid induction of nonneutralizing antibodies (non-NAbs) against PRRSV NSPs after MLV immunization or wild-strain infection is one of the reasons why development of an effective vaccine has been hampered. By using in vitro-generated BMDCs as models...

    Chunyan Wu, Bingjun Shi, Di Yang, Kun Zhang, Jie Li, Jie Wang, Hongliang Liu, Qin Zhao, En-Min Zhou, Yuchen Nan
  • Flow Cytometry Analysis of HIV-1 Env Conformations at the Surface of Infected Cells and Virions: Role of Nef, CD4, and SERINC5
    Pathogenesis and Immunity
    Flow Cytometry Analysis of HIV-1 Env Conformations at the Surface of Infected Cells and Virions: Role of Nef, CD4, and SERINC5

    HIV-1 Env conformation is one of the key parameters determining viral infectivity. The flow virometry-based assay developed in this study allows for the characterization of proteins incorporated in HIV-1 particles. We studied the conformation of HIV-1 Env and the impact that the viral protein Nef and the cellular proteins CD4 and SERINC5 have on Env accessibility to antibodies. Our assay permitted us to highlight some noticeable...

    Isabelle Staropoli, Jérémy Dufloo, Anaïs Ducher, Pierre-Henri Commere, Anna Sartori-Rupp, Sophie Novault, Timothée Bruel, Valérie Lorin, Hugo Mouquet, Olivier Schwartz, Nicoletta Casartelli
  • CD4 Incorporation into HIV-1 Viral Particles Exposes Envelope Epitopes Recognized by CD4-Induced Antibodies
    Pathogenesis and Immunity
    CD4 Incorporation into HIV-1 Viral Particles Exposes Envelope Epitopes Recognized by CD4-Induced Antibodies

    It has been well established that Env-CD4 complexes expose epitopes recognized by commonly elicited CD4-induced antibodies at the surface of HIV-1-infected cells, rendering them vulnerable to ADCC responses. Here, we show that CD4 incorporation has a profound impact on Env conformation at the surface of viral particles. Incorporated CD4 exposes CD4-induced epitopes on Env, rendering HIV-1 susceptible to neutralization by otherwise...

    Shilei Ding, Romain Gasser, Gabrielle Gendron-Lepage, Halima Medjahed, William D. Tolbert, Joseph Sodroski, Marzena Pazgier, Andrés Finzi
  • Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env
    Virus-Cell Interactions
    Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env

    HIV-1 has evolved to acquire several strategies to limit the exposure of its envelope glycoproteins (Env) on the surface of infected cells. In this study, we show that antibody-induced Env internalization is conformation specific and reduces the susceptibility of infected cells to antibody-dependent cellular cytotoxicity (ADCC). Thus, a better understanding of this mechanism might help develop antibodies with improved capacities to...

    Sai Priya Anand, Jonathan R. Grover, William D. Tolbert, Jérémie Prévost, Jonathan Richard, Shilei Ding, Sophie Baril, Halima Medjahed, David T. Evans, Marzena Pazgier, Walther Mothes, Andrés Finzi
  • Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells
    Pathogenesis and Immunity
    Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells

    The “open” CD4-bound conformation of HIV-1 envelope glycoproteins is the primary target of antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies present in HIV-positive (HIV+) sera, such as anti-coreceptor binding site and anti-cluster A antibodies. Here we report that the binding of these two families of antibodies is required to engage FcγRIIIa and mediate ADCC.

    Sai Priya Anand, Jérémie Prévost, Sophie Baril, Jonathan Richard, Halima Medjahed, Jean-Philippe Chapleau, William D. Tolbert, Sharon Kirk, Amos B. Smith, Bruce D. Wines, Stephen J. Kent, P. Mark Hogarth, Matthew S. Parsons, Marzena Pazgier, Andrés Finzi
  • Cellular Response to Infection
    Frequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load

    The HIV epidemic in southern Africa accounts for almost half of the global HIV burden, with HIV-1 clade C being the predominant strain. It is therefore important to define immune correlates of clade C HIV control that might have implications for vaccine design in this region. T follicular helper (Tfh) cells are critical for the development of HIV-specific antibody responses and could play a role in viral control. Here we showed that the...

    Omolara Baiyegunhi, Bongiwe Ndlovu, Funsho Ogunshola, Nasreen Ismail, Bruce D. Walker, Thumbi Ndung'u, Zaza M. Ndhlovu
  • Open Access
    Vaccines and Antiviral Agents
    HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis
    Saintedym Wills, Kwan-Ki Hwang, Pinghuang Liu, S. Moses Dennison, Matthew Zirui Tay, Xiaoying Shen, Justin Pollara, Judith T. Lucas, Robert Parks, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Jaranit Kaewkungwal, Rasmi Thomas, Jerome H. Kim, Nelson L. Michael, Merlin L. Robb, Mike McRaven, David C. Montefiori, Thomas J. Hope, Hua-Xin Liao, M. Anthony Moody, Guido Ferrari, Barton F. Haynes, S. Munir Alam, Mattia Bonsignori, Georgia D. Tomaras
  • Pathogenesis and Immunity
    BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity
    Jonathan Richard, Jérémie Prévost, Benjamin von Bredow, Shilei Ding, Nathalie Brassard, Halima Medjahed, Mathieu Coutu, Bruno Melillo, Frédéric Bibollet-Ruche, Beatrice H. Hahn, Daniel E. Kaufmann, Amos B. Smith, Joseph Sodroski, Daniel Sauter, Frank Kirchhoff, Katrina Gee, Stuart J. Neil, David T. Evans, Andrés Finzi
  • Vaccines and Antiviral Agents
    Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies
    Timothée Bruel, Florence Guivel-Benhassine, Valérie Lorin, Hugues Lortat-Jacob, Françoise Baleux, Katia Bourdic, Nicolas Noël, Olivier Lambotte, Hugo Mouquet, Olivier Schwartz

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