nitric oxide
Genome Replication and Regulation of Viral Gene ExpressionInterferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent MannerOur results showed that IFN-γ significantly inhibited VZV replication in a cell line-dependent manner. IFN-γ inhibited VZV gene expression after the immediate early stage of infection and abrogated IE62-mediated transactivation. These results suggest that IFN-γ blocks VZV replication by inhibiting IE62 function in a cell line-dependent manner. Understanding the mechanisms by which IFN-γ plays a role in VZV gene programming may be...
Transformation and OncogenesisOncogenic Kaposi’s Sarcoma-Associated Herpesvirus Upregulates Argininosuccinate Synthase 1, a Rate-Limiting Enzyme of the Citrulline-Nitric Oxide Cycle, To Activate the STAT3 Pathway and Promote Growth TransformationWe have previously shown that Kaposi’s sarcoma-associated herpesvirus (KSHV)-transformed cells depend on glutamine rather than glucose for energy production and amino acid and nucleotide syntheses. In this study, we have further examined how the KSHV-reprogramed metabolic pathways are regulated and discovered that KSHV hijacks the citrulline-nitric oxide (NO) cycle to promote growth proliferation and transformation. Multiple KSHV-...
- Pathogenesis and ImmunityRole of Nitric Oxide in the Pathogenesis of Encephalomyocarditis Virus-Induced Diabetes in Mice
- Pathogenesis and ImmunityNitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus
- Pathogenesis and ImmunityNitric Oxide as an Endogenous Mutagen for Sendai Virus without Antiviral Activity