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nitric oxide

  • Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner
    Genome Replication and Regulation of Viral Gene Expression
    Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner

    Our results showed that IFN-γ significantly inhibited VZV replication in a cell line-dependent manner. IFN-γ inhibited VZV gene expression after the immediate early stage of infection and abrogated IE62-mediated transactivation. These results suggest that IFN-γ blocks VZV replication by inhibiting IE62 function in a cell line-dependent manner. Understanding the mechanisms by which IFN-γ plays a role in VZV gene programming may be...

    Akhalesh K. Shakya, Dennis J. O’Callaghan, Seong K. Kim
  • Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus Upregulates Argininosuccinate Synthase 1, a Rate-Limiting Enzyme of the Citrulline-Nitric Oxide Cycle, To Activate the STAT3 Pathway and Promote Growth Transformation
    Transformation and Oncogenesis
    Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus Upregulates Argininosuccinate Synthase 1, a Rate-Limiting Enzyme of the Citrulline-Nitric Oxide Cycle, To Activate the STAT3 Pathway and Promote Growth Transformation

    We have previously shown that Kaposi’s sarcoma-associated herpesvirus (KSHV)-transformed cells depend on glutamine rather than glucose for energy production and amino acid and nucleotide syntheses. In this study, we have further examined how the KSHV-reprogramed metabolic pathways are regulated and discovered that KSHV hijacks the citrulline-nitric oxide (NO) cycle to promote growth proliferation and transformation. Multiple KSHV-...

    Tingting Li, Ying Zhu, Fan Cheng, Chun Lu, Jae U. Jung, Shou-Jiang Gao
  • Open Access
    Virus-Cell Interactions
    Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production
    Mia Madel Alfajaro, Jong-Soon Choi, Deok-Song Kim, Ja-Young Seo, Ji-Yun Kim, Jun-Gyu Park, Mahmoud Soliman, Yeong-Bin Baek, Eun-Hyo Cho, Joseph Kwon, Hyung-Jun Kwon, Su-Jin Park, Woo Song Lee, Mun-Il Kang, Myra Hosmillo, Ian Goodfellow, Kyoung-Oh Cho
  • Pathogenesis and Immunity
    Role of Nitric Oxide in the Pathogenesis of Encephalomyocarditis Virus-Induced Diabetes in Mice
    Young-Sun Lee, Na Li, Seungjin Shin, Hee-Sook Jun
  • Pathogenesis and Immunity
    Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus
    Sara Åkerström, Mehrdad Mousavi-Jazi, Jonas Klingström, Mikael Leijon, Åke Lundkvist, Ali Mirazimi
  • Pathogenesis and Immunity
    Macrophages Kill Human Papillomavirus Type 16 E6-Expressing Tumor Cells by Tumor Necrosis Factor Alpha- and Nitric Oxide-Dependent Mechanisms
    John M. Routes, Kristin Morris, Misoo C. Ellison, Sharon Ryan
  • Pathogenesis and Immunity
    Analysis of Human Peripheral Blood Samples from Fatal and Nonfatal Cases of Ebola (Sudan) Hemorrhagic Fever: Cellular Responses, Virus Load, and Nitric Oxide Levels
    Anthony Sanchez, Matthew Lukwiya, Daniel Bausch, Siddhartha Mahanty, Angela J. Sanchez, Kent D. Wagoner, Pierre E. Rollin
  • Virus-Cell Interactions
    Rabies Virus Stimulates Nitric Oxide Production and CXC Chemokine Ligand 10 Expression in Macrophages through Activation of Extracellular Signal-Regulated Kinases 1 and 2
    Kazuo Nakamichi, Satoshi Inoue, Tomohiko Takasaki, Kinjiro Morimoto, Ichiro Kurane
  • Virus-Cell Interactions
    Hepatitis C Virus Infection Activates the Immunologic (Type II) Isoform of Nitric Oxide Synthase and Thereby Enhances DNA Damage and Mutations of Cellular Genes
    Keigo Machida, Kevin T.-H. Cheng, Vicky M.-H. Sung, Ki Jeong Lee, Alexandra M. Levine, Michael M. C. Lai
  • Pathogenesis and Immunity
    Nitric Oxide as an Endogenous Mutagen for Sendai Virus without Antiviral Activity
    Jun Yoshitake, Takaaki Akaike, Teruo Akuta, Fumio Tamura, Tsutomu Ogura, Hiroyasu Esumi, Hiroshi Maeda

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