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Newcastle disease virus

  • Ionic Strength-Dependent, Reversible Pleomorphism of Recombinant Newcastle Disease Virus
    Structure and Assembly
    Ionic Strength-Dependent, Reversible Pleomorphism of Recombinant Newcastle Disease Virus

    Oncolytic viruses are being developed for cancer therapy, as they selectively target, infect, and kill cancer cells. NDV is particularly attractive because while it is pathogenic to avians (e.g., chickens), it does not cause significant viremia in humans. We have developed a genetically modified recombinant NDV (rNDV) that has much reduced pathogenicity in chickens but is highly oncolytic. The morphology of rNDV transitions from...

    Benjamin S. Rush, Matieyendou Didier Djagbare, Jeffrey A. Speir, Gautam Sanyal
  • Host CARD11 Inhibits Newcastle Disease Virus Replication by Suppressing Viral Polymerase Activity in Neurons
    Virus-Cell Interactions
    Host CARD11 Inhibits Newcastle Disease Virus Replication by Suppressing Viral Polymerase Activity in Neurons

    Newcastle disease virus (NDV) substantially impacts the poultry industry worldwide and causes viral encephalitis and neurological disorders leading to brain damage, paralysis, and death. The mechanism of interaction between this neurotropic virus and the avian central nervous system (CNS) is largely unknown. Here, we report that host protein CARD11 presented brain-specific upregulated expression that inhibited NDV replication, which was...

    Wenbin Wang, Xudong Chang, Wei Yao, Ning Wei, Na Huo, Yanhong Wang, Qiaolin Wei, Haijin Liu, Xinglong Wang, Shuxia Zhang, Zengqi Yang, Sa Xiao
  • Solution Structure, Self-Assembly, and Membrane Interactions of the Matrix Protein from Newcastle Disease Virus at Neutral and Acidic pH
    Structure and Assembly
    Solution Structure, Self-Assembly, and Membrane Interactions of the Matrix Protein from Newcastle Disease Virus at Neutral and Acidic pH

    The matrix protein of the Newcastle disease virus (NDV) is one of the most abundant viral proteins that regulates the formation of progeny virions. NDV is an avian pathogen that impacts the economics of bird husbandry due to its resulting morbidity and high mortality rates. Moreover, it belongs to the Avulavirus subfamily of the Paramyxoviridae family of Mononegavirales that include dangerous representatives...

    E. V. Shtykova, M. V. Petoukhov, L. A. Dadinova, N. V. Fedorova, V. Yu Tashkin, T. A. Timofeeva, A. L. Ksenofontov, N. A. Loshkarev, L. A. Baratova, C. M. Jeffries, D. I. Svergun, O. V. Batishchev
  • Vaccines and Antiviral Agents
    Newcastle Disease Virus-Based Vectored Vaccine against Poliomyelitis

    A new, safe, and effective vaccine against poliovirus is urgently needed not only to complete the eradication of the virus but also to be used in the future to prevent possible virus reemergence in a postpolio world. Currently, new formulations of the oral vaccine, as well as improvements to the inactivated vaccine, are being explored. In this study, we designed a viral vector with mucosal tropism that expresses poliovirus capsid...

    Ekaterina G. Viktorova, Sunil K. Khattar, Diana Kouiavskaia, Majid Laassri, Tatiana Zagorodnyaya, Eugenia Dragunsky, Siba Samal, Konstantin Chumakov, George A. Belov
  • Virus-Cell Interactions
    Newcastle Disease Virus Establishes Persistent Infection in Tumor Cells In Vitro: Contribution of the Cleavage Site of Fusion Protein and Second Sialic Acid Binding Site of Hemagglutinin-Neuraminidase
    Udaya S. Rangaswamy, Weijia Wang, Xing Cheng, Patrick McTamney, Danielle Carroll, Hong Jin
  • Pathogenesis and Immunity
    The Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus
    J. C. F. M. Dortmans, P. J. M. Rottier, G. Koch, B. P. H. Peeters
  • Structure and Assembly
    Assembly and Biological and Immunological Properties of Newcastle Disease Virus-Like Particles
    Lori W. McGinnes, Homer Pantua, Jason P. Laliberte, Kathryn A. Gravel, Surbhi Jain, Trudy G. Morrison
  • Cellular Response to Infection
    Type I Interferon-Sensitive Recombinant Newcastle Disease Virus for Oncolytic Virotherapy
    Subbiah Elankumaran, Vrushali Chavan, Dan Qiao, Raghunath Shobana, Gopakumar Moorkanat, Moanaro Biswas, Siba K. Samal
  • Genome Replication and Regulation of Viral Gene Expression
    Role of Untranslated Regions in Regulation of Gene Expression, Replication, and Pathogenicity of Newcastle Disease Virus Expressing Green Fluorescent Protein
    Shin-Hee Kim, Siba K. Samal
  • Vaccines and Antiviral Agents
    Newcastle Disease Virus-Vectored Vaccines Expressing the Hemagglutinin or Neuraminidase Protein of H5N1 Highly Pathogenic Avian Influenza Virus Protect against Virus Challenge in Monkeys
    Joshua M. DiNapoli, Baibaswata Nayak, Lijuan Yang, Brad W. Finneyfrock, Anthony Cook, Hanne Andersen, Fernando Torres-Velez, Brian R. Murphy, Siba K. Samal, Peter L. Collins, Alexander Bukreyev

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