Newcastle disease virus
Structure and AssemblyIonic Strength-Dependent, Reversible Pleomorphism of Recombinant Newcastle Disease VirusOncolytic viruses are being developed for cancer therapy, as they selectively target, infect, and kill cancer cells. NDV is particularly attractive because while it is pathogenic to avians (e.g., chickens), it does not cause significant viremia in humans. We have developed a genetically modified recombinant NDV (rNDV) that has much reduced pathogenicity in chickens but is highly oncolytic. The morphology of rNDV transitions from...
Virus-Cell InteractionsHost CARD11 Inhibits Newcastle Disease Virus Replication by Suppressing Viral Polymerase Activity in NeuronsNewcastle disease virus (NDV) substantially impacts the poultry industry worldwide and causes viral encephalitis and neurological disorders leading to brain damage, paralysis, and death. The mechanism of interaction between this neurotropic virus and the avian central nervous system (CNS) is largely unknown. Here, we report that host protein CARD11 presented brain-specific upregulated expression that inhibited NDV replication, which was...
Structure and AssemblySolution Structure, Self-Assembly, and Membrane Interactions of the Matrix Protein from Newcastle Disease Virus at Neutral and Acidic pHThe matrix protein of the Newcastle disease virus (NDV) is one of the most abundant viral proteins that regulates the formation of progeny virions. NDV is an avian pathogen that impacts the economics of bird husbandry due to its resulting morbidity and high mortality rates. Moreover, it belongs to the Avulavirus subfamily of the Paramyxoviridae family of Mononegavirales that include dangerous representatives...
- Vaccines and Antiviral AgentsNewcastle Disease Virus-Based Vectored Vaccine against Poliomyelitis
A new, safe, and effective vaccine against poliovirus is urgently needed not only to complete the eradication of the virus but also to be used in the future to prevent possible virus reemergence in a postpolio world. Currently, new formulations of the oral vaccine, as well as improvements to the inactivated vaccine, are being explored. In this study, we designed a viral vector with mucosal tropism that expresses poliovirus capsid...
- Pathogenesis and ImmunityThe Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus
- Cellular Response to InfectionType I Interferon-Sensitive Recombinant Newcastle Disease Virus for Oncolytic Virotherapy
- Genome Replication and Regulation of Viral Gene ExpressionRole of Untranslated Regions in Regulation of Gene Expression, Replication, and Pathogenicity of Newcastle Disease Virus Expressing Green Fluorescent Protein