Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Minireviews
    • JVI Classic Spotlights
    • Archive
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About JVI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Journal of Virology
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Minireviews
    • JVI Classic Spotlights
    • Archive
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About JVI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions

MERS-CoV

  • Free
    Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in Mice
    Pathogenesis and Immunity
    Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in Mice

    Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus causing human infections with high mortality rate (∼35%). Animal models together with reverse-genetics systems are essential to understand MERS-CoV pathogenesis. We developed a reverse-genetics system for a mouse-adapted MERS-CoV that reproduces the virus behavior observed in humans. This system is highly useful to investigate the role of specific viral genes in...

    Javier Gutierrez-Alvarez, Li Wang, Raul Fernandez-Delgado, Kun Li, Paul B. McCray, Stanley Perlman, Isabel Sola, Sonia Zuñiga, Luis Enjuanes
  • Open Access
    Cross-Protection against MERS-CoV by Prime-Boost Vaccination Using Viral Spike DNA and Protein
    Vaccines and Antiviral Agents
    Cross-Protection against MERS-CoV by Prime-Boost Vaccination Using Viral Spike DNA and Protein

    Coronavirus is an RNA virus with a higher mutation rate than DNA viruses. Therefore, a mutation in S-protein, which mediates viral infection by binding to a human cellular receptor, is expected to cause difficulties in vaccine development. Given that DNA-protein vaccines promote stronger cell-mediated immune responses than protein-only vaccination, we immunized mice with various combinations of DNA priming and protein boosting using the...

    Jung-ah Choi, Junghyun Goo, Eunji Yang, Dae-Im Jung, Sena Lee, Semi Rho, Yuji Jeong, Young-Shin Park, Hayan Park, Young-hye Moon, Uni Park, Sang-Hwan Seo, Hyeja Lee, Jae Myun Lee, Nam-Hyuk Cho, Manki Song, Jae-Ouk Kim
  • Increased Pathogenicity and Virulence of Middle East Respiratory Syndrome Coronavirus Clade B <em>In Vitro</em> and <em>In Vivo</em>
    Pathogenesis and Immunity
    Increased Pathogenicity and Virulence of Middle East Respiratory Syndrome Coronavirus Clade B In Vitro and In Vivo

    MERS-CoV is an important emerging pathogen and causes severe respiratory infection in humans. MERS-CoV strains from early epidemic clade A and contemporary epidemic clade B have not been phenotypically characterized to compare their abilities to infect cells and mice. In this study, we showed that a clade B virus ChinaGD01 strain caused more severe disease in mice, with delayed viral clearance, increased inflammatory cytokines, and...

    Yanqun Wang, Jing Sun, Xiaobo Li, Airu Zhu, Wenda Guan, De-Qiang Sun, Mian Gan, Xuefeng Niu, Jun Dai, Lu Zhang, Zhaoyong Zhang, Yongxia Shi, Shuxiang Huang, Chris Ka Pun Mok, Zifeng Yang, Zhongfang Wang, Wenjie Tan, Yimin Li, Ling Chen, Rongchang Chen, Malik Peiris, Nanshan Zhong, Jingxian Zhao, Jicheng Huang, Jincun Zhao
  • Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Suppresses Type I and Type III Interferon Induction by Targeting RIG-I Signaling
    Virus-Cell Interactions
    Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Suppresses Type I and Type III Interferon Induction by Targeting RIG-I Signaling

    MERS-CoV causes death of about 35% of patients. Published studies showed that some coronaviruses are capable of suppressing interferon (IFN) expression in the early phase of infection and MERS-CoV proteins can modulate host immune response. In this study, we demonstrated that MERS-CoV nucleocapsid (N) protein suppresses the production of both type I and type III IFNs via sequestering TRIM25, an E3 ubiquitin ligase that is essential for...

    Chi-You Chang, Helene Minyi Liu, Ming-Fu Chang, Shin C. Chang
  • Molecular Basis of Binding between Middle East Respiratory Syndrome Coronavirus and CD26 from Seven Bat Species
    Structure and Assembly
    Molecular Basis of Binding between Middle East Respiratory Syndrome Coronavirus and CD26 from Seven Bat Species

    In this study, we found that bat CD26s (bCD26s) from different species exhibit large diversities, especially in the region responsible for binding to the receptor binding domain (RBD) of Middle East respiratory syndrome coronavirus (MERS-CoV). However, they maintain the interaction with MERS-RBD at varied affinities and support the entry of pseudotyped MERS-CoV. These bat receptors polymorphisms seem to confer evolutionary pressure for...

    Yuan Yuan, Jianxun Qi, Ruchao Peng, Chunrui Li, Guangwen Lu, Jinghua Yan, Qihui Wang, George Fu Gao
  • Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection
    Virus-Cell Interactions | Spotlight
    Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection

    Overall, our studies demonstrate that proteolytic cleavage is the primary barrier to infection for a subset of zoonotic coronaviruses. Moving forward, the results argue that both receptor binding and proteolytic cleavage of the spike are critical factors that must be considered for evaluating the emergence potential and risk posed by zoonotic coronaviruses. In addition, the findings also offer a novel means to recover previously...

    Vineet D. Menachery, Kenneth H. Dinnon, Boyd L. Yount, Eileen T. McAnarney, Lisa E. Gralinski, Andrew Hale, Rachel L. Graham, Trevor Scobey, Simon J. Anthony, Lingshu Wang, Barney Graham, Scott H. Randell, W. Ian Lipkin, Ralph S. Baric
  • Small-Molecule Antiviral β-<span class="sc">d</span>-<em>N</em><sup>4</sup>-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
    Vaccines and Antiviral Agents
    Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

    The emergence of coronaviruses (CoVs) into human populations from animal reservoirs has demonstrated their epidemic capability, pandemic potential, and ability to cause severe disease. However, no antivirals have been approved to treat these infections. Here, we demonstrate the potent antiviral activity of a broad-spectrum ribonucleoside analogue, β-d-N4-hydroxycytidine (NHC), against two...

    Maria L. Agostini, Andrea J. Pruijssers, James D. Chappell, Jennifer Gribble, Xiaotao Lu, Erica L. Andres, Gregory R. Bluemling, Mark A. Lockwood, Timothy P. Sheahan, Amy C. Sims, Michael G. Natchus, Manohar Saindane, Alexander A. Kolykhalov, George R. Painter, Ralph S. Baric, Mark R. Denison
  • Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity
    Vaccines and Antiviral Agents
    Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity

    In this article, we consider a role for bacteria in shaping coronavirus infection. Taking cues from studies of enteric viruses, we initially investigated how bacterial surface components might improve CoV infection. Instead, we found that peptidoglycan-associated surfactin is a potent viricidal compound that disrupts virion integrity with broad activity against enveloped viruses. Our results indicate that interactions with commensal...

    Bryan A. Johnson, Adam Hage, Birte Kalveram, Megan Mears, Jessica A. Plante, Sergio E. Rodriguez, Zhixia Ding, Xuemei Luo, Dennis Bente, Shelton S. Bradrick, Alexander N. Freiberg, Vsevolod Popov, Ricardo Rajsbaum, Shannan Rossi, William K. Russell, Vineet D. Menachery
  • A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication
    Virus-Cell Interactions
    A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication

    Middle East respiratory syndrome coronavirus (MERS-CoV) initially emerged in 2012 and has since been responsible for over 2,300 infections, with a case fatality ratio of approximately 35%. We have used the highly characterized model system of Saccharomyces cerevisiae to investigate novel functional interactions between viral proteins and eukaryotic cells that may...

    Stuart Weston, Krystal L. Matthews, Rachel Lent, Alexandra Vlk, Rob Haupt, Tami Kingsbury, Matthew B. Frieman
  • Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus
    Pathogenesis and Immunity
    Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus

    Middle East respiratory syndrome coronavirus (MERS-CoV) infections are endemic in the Middle East and a threat to public health worldwide. Rodents are not susceptible to the virus because they do not express functional receptors; therefore, we generated a new animal model of MERS-CoV infection based on transgenic mice expressing human DPP4 (hDPP4). The pattern of hDPP4 expression in this model was similar to that in human tissues (...

    Naoko Iwata-Yoshikawa, Tadashi Okamura, Yukiko Shimizu, Osamu Kotani, Hironori Sato, Hanako Sekimukai, Shuetsu Fukushi, Tadaki Suzuki, Yuko Sato, Makoto Takeda, Masato Tashiro, Hideki Hasegawa, Noriyo Nagata

Pages

  • Next
  • 1
  • 2
Back to top

About

  • About JVI
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #Jvirology

@ASMicrobiology

       

 

JVI in collaboration with

American Society for Virology

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0022-538X; Online ISSN: 1098-5514