membraneless cytoplasmic organelles

  • Human Antiviral Protein MxA Forms Novel Metastable Membraneless Cytoplasmic Condensates Exhibiting Rapid Reversible Tonicity-Driven Phase Transitions
    Cellular Response to Infection
    Human Antiviral Protein MxA Forms Novel Metastable Membraneless Cytoplasmic Condensates Exhibiting Rapid Reversible Tonicity-Driven Phase Transitions

    There is a long-standing belief that interferon (IFN)-inducible human myxovirus resistance protein A (MxA), which displays antiviral activity against several RNA and DNA viruses, associates with the endoplasmic reticulum (ER) and Golgi apparatus. We provide data to correct this misinterpretation and further report that MxA forms membraneless metastable (shape-changing) condensates in the cytoplasm consisting of variably sized spherical...

    Deodate Davis, Huijuan Yuan, Feng-Xia Liang, Yang-Ming Yang, Jenna Westley, Chris Petzold, Kristen Dancel-Manning, Yan Deng, Joseph Sall, Pravin B. Sehgal
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