membrane trafficking
Structure and Assembly | SpotlightHerpes Simplex Virus Organizes Cytoplasmic Membranes To Form a Viral Assembly Center in Neuronal CellsHerpesvirus particles are complex and contain many different proteins that must come together in an organized and coordinated fashion. Many viruses solve this coordination problem by creating a specialized assembly factory in the host cell, and the formation of such factories provides a promising target for interfering with virus production. Herpes simplex virus 1 (HSV-1) infects several types of cells, including neurons, but has not...
Virus-Cell Interactions | SpotlightHIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4+ T CellsHIV infection modulates the surface expression of Tim-3, but the molecular determinants remain poorly understood. Here, we show that HIV-1 Vpu downregulates Tim-3 from the surface of infected primary CD4+ T cells through its transmembrane domain and alters its subcellular localization. Tim-3 blockade increases HIV-1 replication, suggesting a potential negative role of this protein in viral spread that is counteracted by Vpu...