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membrane proteins

  • Characterization of the Herpes Simplex Virus (HSV) Tegument Proteins That Bind to gE/gI and US9, Which Promote Assembly of HSV and Transport into Neuronal Axons
    Virus-Cell Interactions | Spotlight
    Characterization of the Herpes Simplex Virus (HSV) Tegument Proteins That Bind to gE/gI and US9, Which Promote Assembly of HSV and Transport into Neuronal Axons

    Herpes simplex viruses 1 and 2 and varicella-zoster virus cause significant morbidity and mortality. One basic property of these viruses is the capacity to establish latency in the sensory neurons and to reactivate from latency and then cause disease in peripheral tissues, such as skin and mucosal epithelia. The transport of nascent HSV particles from neuron cell bodies into axons and along axons to axon tips in the periphery is an...

    Grayson DuRaine, Todd W. Wisner, David C. Johnson
  • Mapping the Nonstructural Protein Interaction Network of Porcine Reproductive and Respiratory Syndrome Virus
    Structure and Assembly | Spotlight
    Mapping the Nonstructural Protein Interaction Network of Porcine Reproductive and Respiratory Syndrome Virus

    Synthesis of PRRSV RNAs within host cells depends on the efficient and correct assembly of RTC that takes places on modified intracellular membranes. As an important step toward dissecting this poorly understood event, we investigated the interaction network among PRRSV nsps. Our studies established a comprehensive interaction map for PRRSV nsps and revealed important players within the network. The results also highlight the likely...

    Jiangwei Song, Yuanyuan Liu, Peng Gao, Yunhao Hu, Yue Chai, Shaochuan Zhou, Can Kong, Lei Zhou, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang
  • Localization and Regulation of the T1 Unimolecular Spanin
    Virus-Cell Interactions
    Localization and Regulation of the T1 Unimolecular Spanin

    Spanins have been proposed to fuse the cytoplasmic and outer membranes during phage lysis. Recent work with the lambda spanins Rz-Rz1, which are similar to class I viral fusion proteins, has shed light on the functional domains and requirements for two-component spanin function. Here we report, for the first time, a genetic and biochemical approach to characterize unimolecular spanins, which are structurally and mechanistically...

    Rohit Kongari, Jeffrey Snowden, Joel D. Berry, Ry Young
  • Structure and Assembly
    Domains of the Hepatitis B Virus Small Surface Protein S Mediating Oligomerization
    Sascha Suffner, Nadine Gerstenberg, Maria Patra, Paula Ruibal, Ahmed Orabi, Michael Schindler, Volker Bruss
  • Genome Replication and Regulation of Viral Gene Expression
    Glycine Zipper Motifs in Hepatitis C Virus Nonstructural Protein 4B Are Required for the Establishment of Viral Replication Organelles
    David Paul, Vanesa Madan, Omar Ramirez, Maja Bencun, Ina Karen Stoeck, Vlastimil Jirasko, Ralf Bartenschlager
  • Open Access
    Pathogenesis and Immunity
    Proteomic and Functional Analyses of the Virion Transmembrane Proteome of Cyprinid Herpesvirus 3
    Catherine Vancsok, M. Michelle D. Peñaranda, V. Stalin Raj, Baptiste Leroy, Joanna Jazowiecka-Rakus, Maxime Boutier, Yuan Gao, Gavin S. Wilkie, Nicolás M. Suárez, Ruddy Wattiez, Laurent Gillet, Andrew J. Davison, Alain F. C. Vanderplasschen
  • Open Access
    Virus-Cell Interactions
    Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection
    Torsten Schaller, Lorenzo Bulli, Darja Pollpeter, Gilberto Betancor, Juliane Kutzner, Luis Apolonia, Nikolas Herold, Robin Burk, Michael H. Malim
  • Virus-Cell Interactions
    Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1
    Thibaut Deschamps, Maria Kalamvoki
  • Free
    Gem
    Collateral Damage during Dengue Virus Infection: Making Sense of DNA by cGAS
    Sebastian Aguirre, Ana Fernandez-Sesma
  • Virus-Cell Interactions | Spotlight
    Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection
    Atsushi Tanaka, Uranan Tumkosit, Shota Nakamura, Daisuke Motooka, Natsuko Kishishita, Thongkoon Priengprom, Areerat Sa-ngasang, Taroh Kinoshita, Naokazu Takeda, Yusuke Maeda

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