membrane proteins
Virus-Cell Interactions | SpotlightCharacterization of the Herpes Simplex Virus (HSV) Tegument Proteins That Bind to gE/gI and US9, Which Promote Assembly of HSV and Transport into Neuronal AxonsHerpes simplex viruses 1 and 2 and varicella-zoster virus cause significant morbidity and mortality. One basic property of these viruses is the capacity to establish latency in the sensory neurons and to reactivate from latency and then cause disease in peripheral tissues, such as skin and mucosal epithelia. The transport of nascent HSV particles from neuron cell bodies into axons and along axons to axon tips in the periphery is an...
Structure and Assembly | SpotlightMapping the Nonstructural Protein Interaction Network of Porcine Reproductive and Respiratory Syndrome VirusSynthesis of PRRSV RNAs within host cells depends on the efficient and correct assembly of RTC that takes places on modified intracellular membranes. As an important step toward dissecting this poorly understood event, we investigated the interaction network among PRRSV nsps. Our studies established a comprehensive interaction map for PRRSV nsps and revealed important players within the network. The results also highlight the likely...
Virus-Cell InteractionsLocalization and Regulation of the T1 Unimolecular SpaninSpanins have been proposed to fuse the cytoplasmic and outer membranes during phage lysis. Recent work with the lambda spanins Rz-Rz1, which are similar to class I viral fusion proteins, has shed light on the functional domains and requirements for two-component spanin function. Here we report, for the first time, a genetic and biochemical approach to characterize unimolecular spanins, which are structurally and mechanistically...
- Structure and AssemblyDomains of the Hepatitis B Virus Small Surface Protein S Mediating Oligomerization
- Genome Replication and Regulation of Viral Gene ExpressionGlycine Zipper Motifs in Hepatitis C Virus Nonstructural Protein 4B Are Required for the Establishment of Viral Replication Organelles
- Pathogenesis and ImmunityProteomic and Functional Analyses of the Virion Transmembrane Proteome of Cyprinid Herpesvirus 3
- Virus-Cell InteractionsEvasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1
- Virus-Cell Interactions | SpotlightGenome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection