measles
Virus-Cell InteractionsAnalysis of a Subacute Sclerosing Panencephalitis Genotype B3 Virus from the 2009-2010 South African Measles Epidemic Shows That Hyperfusogenic F Proteins Contribute to Measles Virus Infection in the BrainMeasles virus can invade the central nervous system (CNS) and cause severe neurological complications, such as MIBE and SSPE. However, mechanisms by which MeV enters the CNS and triggers the disease remain unclear. We analyzed viruses from brain tissue of individuals with MIBE or SSPE, infected during the same epidemic, after the onset of neurological disease. Our findings indicate that the emergence of hyperfusogenic MeV F proteins is...
Virus-Cell InteractionsStructure-Guided Identification of a Nonhuman Morbillivirus with Zoonotic PotentialA significant proportion of viral pandemics occur following zoonotic transmission events, where animal-associated viruses jump species into human populations. In order to provide forewarnings of the emergence of these viruses, it is necessary to develop a better understanding of what determines virus host range, often at the genetic and structural levels. In this study, we demonstrated that the small-ruminant morbillivirus, a close...
- Virus-Cell InteractionsThe Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis
- Pathogenesis and ImmunityClearance of Measles Virus from Persistently Infected Cells by Short Hairpin RNA