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Lyssavirus

  • Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor
    Vaccines and Antiviral Agents | Spotlight
    Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor

    Rabies PEP depends on anti-RABV IgG, which is expensive and in limited supply in geographical areas with the highest disease burden. Replacing the IgG component with a cost-effective and shelf-stable small-molecule antiviral could address this unmet clinical need by expanding access to life-saving medication. This study has established a robust protocol for high-throughput anti-RABV drug screens and identified a chemically well-behaved...

    Venice Du Pont, Christoph Wirblich, Jeong-Joong Yoon, Robert M. Cox, Matthias J. Schnell, Richard K. Plemper
  • Genetic Diversity and Evolution
    Quantifying Antigenic Relationships among the Lyssaviruses
    D. L. Horton, L. M. McElhinney, D. A. Marston, J. L. N. Wood, C. A. Russell, N. Lewis, I. V. Kuzmin, R. A. M. Fouchier, A. D. M. E. Osterhaus, A. R. Fooks, D. J. Smith
  • Virus-Cell Interactions
    Two Overlapping Domains of a Lyssavirus Matrix Protein That Acts on Different Cell Death Pathways
    Florence Larrous, Alireza Gholami, Shahul Mouhamad, Jérôme Estaquier, Hervé Bourhy
  • Virus-Cell Interactions
    Intergenotypic Replacement of Lyssavirus Matrix Proteins Demonstrates the Role of Lyssavirus M Proteins in Intracellular Virus Accumulation
    Stefan Finke, Harald Granzow, Jose Hurst, Reiko Pollin, Thomas C. Mettenleiter
  • Structure and Assembly
    Structure of the Nucleoprotein Binding Domain of Mokola Virus Phosphoprotein
    René Assenberg, Olivier Delmas, Jingshan Ren, Pierre-Olivier Vidalain, Anil Verma, Florence Larrous, Stephen C. Graham, Frédéric Tangy, Jonathan M. Grimes, Hervé Bourhy
  • Virus-Cell Interactions
    Mitochondrial Dysfunction in Lyssavirus-Induced Apoptosis
    Alireza Gholami, Raïd Kassis, Eléonore Real, Olivier Delmas, Stéphanie Guadagnini, Florence Larrous, Dorothée Obach, Marie-Christine Prevost, Yves Jacob, Hervé Bourhy
  • Genetic Diversity and Evolution
    Phylogeography, Population Dynamics, and Molecular Evolution of European Bat Lyssaviruses
    Patricia L. Davis, Edward C. Holmes, Florence Larrous, Wim H. M. Van der Poel, Kirsten Tjørnehøj, Wladimir J. Alonso, Hervé Bourhy
  • Virus-Cell Interactions
    Lyssavirus Matrix Protein Induces Apoptosis by a TRAIL-Dependent Mechanism Involving Caspase-8 Activation
    Raïd Kassis, Florence Larrous, Jérôme Estaquier, Hervé Bourhy
  • REPLICATION
    A Novel Expression Cassette of Lyssavirus Shows that the Distantly Related Mokola Virus Can Rescue a Defective Rabies Virus Genome
    Philippe Le Mercier, Yves Jacob, Kyle Tanner, Noël Tordo
  • REPLICATION
    Functional Interaction Map of Lyssavirus Phosphoprotein: Identification of the Minimal Transcription Domains
    Yves Jacob, Eléonore Real, Noël Tordo

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