lectins
Vaccines and Antiviral AgentsThe High Content of Fructose in Human Semen Competitively Inhibits Broad and Potent Antivirals That Target High-Mannose GlycansBiological secretions allow viruses to spread between individuals. Each type of secretion has a unique composition of proteins, salts, and sugars, which can affect the infectivity potential of the virus and inhibition of this process. Here, we describe HIV-1 infection and inhibition in whole human seminal plasma and a synthetic simulant that we formulated. We discovered that the sugar fructose in semen decreases the activity of a broad...
- Virus-Cell InteractionsC-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans