Lassa fever
Pathogenesis and ImmunitySevere Human Lassa Fever Is Characterized by Nonspecific T-Cell Activation and Lymphocyte Homing to Inflamed TissuesLassa fever may cause severe disease in humans, in particular in areas of endemicity like Sierra Leone and Nigeria. Despite its public health importance, the pathophysiology of Lassa fever in humans is poorly understood. Here, we present clinical immunology data obtained in the field during the 2018 Lassa fever outbreak in Nigeria indicating that severe Lassa fever is associated with activation of T cells antigenically unrelated to...
Pathogenesis and ImmunityIdentification of Common CD8+ T Cell Epitopes from Lassa Fever Survivors in Nigeria and Sierra LeoneThe high morbidity and mortality associated with clinical cases of Lassa fever, together with the lack of licensed vaccines and limited and partially effective interventions, make Lassa virus (LASV) an important health concern in its regions of endemicity in West Africa. Previous infection with LASV protects from disease after subsequent exposure, providing a framework for designing vaccines to elicit similar protective immunity....
- Pathogenesis and ImmunityEarly Blood Profiles of Virus Infection in a Monkey Model for Lassa Fever
- Vaccines and Antiviral AgentsA Live Attenuated Vaccine for Lassa Fever Made by Reassortment of Lassa and Mopeia Viruses
- Vaccines and Antiviral AgentsEffective Vaccine for Lassa Fever