Interleukin-2

Pathogenesis and Immunity
Mononucleosis and Antigen-Driven T Cell Responses Have Different Requirements for Interleukin-2 Signaling in Murine Gammaherpesvirus Infection
Michael Molloy, Weijun Zhang, Edward Usherwood
Pathogenesis and Immunity
Human Immunodeficiency Virus Type 1 Escapes from Interleukin-2-Producing CD4⁺ T-Cell Responses without High-Frequency Fixation of Mutations
R. Brad Jones, Feng-Yun Yue, Xiao Xiao Jenny Gu, Diana V. Hunter, Shariq Mujib, Gabor Gyenes, Rosemarie D. Mason, Ruqaya Mohamed, Kelly S. MacDonald, Colin Kovacs, Mario A. Ostrowski
Virus-Cell Interactions
Comparisons of CD8⁺ T Cells Specific for Human Immunodeficiency Virus, Hepatitis C Virus, and Cytomegalovirus Reveal Differences in Frequency, Immunodominance, Phenotype, and Interleukin-2 Responsiveness
Prasanna Jagannathan, Christine M. Osborne, Cassandra Royce, Maura M. Manion, John C. Tilton, Li Li, Steven Fischer, Claire W. Hallahan, Julia A. Metcalf, Mary McLaughlin, Matthew Pipeling, John F. McDyer, Thomas J. Manley, Jeffery L. Meier, John D. Altman, Laura Hertel, Richard T. Davey, Mark Connors, Stephen A. Migueles
Vaccines and Antiviral Agents
Increased Immunogenicity of a DNA-Launched Venezuelan Equine Encephalitis Virus-Based Replicon DNA Vaccine
Karl Ljungberg, Alan C. Whitmore, Meagan E. Fluet, Timothy P. Moran, Reed S. Shabman, Martha L. Collier, Annette A. Kraus, Joseph M. Thompson, David C. Montefiori, Clayton Beard, Robert E. Johnston
Transformation and Oncogenesis
Cooperation of NF-κB2/p100 Activation and the PDZ Domain Binding Motif Signal in Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax1 but Not HTLV-2 Tax2 Is Crucial for Interleukin-2-Independent Growth Transformation of a T-Cell Line
Masaya Higuchi, Chikako Tsubata, Rie Kondo, Sakiko Yoshida, Masahiko Takahashi, Masayasu Oie, Yuetsu Tanaka, Renaud Mahieux, Masao Matsuoka, Masahiro Fujii
Pathogenesis and Immunity
Changes in Paracrine Interleukin-2 Requirement, CCR7 Expression, Frequency, and Cytokine Secretion of Human Immunodeficiency Virus-Specific CD4⁺ T Cells Are a Consequence of Antigen Load
John C. Tilton, Marlise R. Luskin, Alison J. Johnson, Maura Manion, Claire W. Hallahan, Julia A. Metcalf, Mary McLaughlin, Richard T. Davey, Mark Connors
Vaccines and Antiviral Agents | Spotlight
Live Attenuated Influenza Virus Expressing Human Interleukin-2 Reveals Increased Immunogenic Potential in Young and Aged Hosts
Boris Ferko, Christian Kittel, Julia Romanova, Sabine Sereinig, Hermann Katinger, Andrej Egorov
Pathogenesis and Immunity | Spotlight
Pulmonary Immunity to Viral Infection: Adenovirus Infection of Lung Dendritic Cells Renders T Cells Nonresponsive to Interleukin-2
Allison T. Thiele, Tina L. Sumpter, Joanna A. Walker, Qi Xu, Cheong-Hee Chang, Robert L. Bacallao, Rajesh Kher, David S. Wilkes
Transformation and Oncogenesis | Spotlight
Aberrant Activation of the Interleukin-2 Autocrine Loop through the Nuclear Factor of Activated T Cells by Nonleukemogenic Human T-Cell Leukemia Virus Type 2 but Not by Leukemogenic Type 1 Virus
Akiko Niinuma, Masaya Higuchi, Masahiko Takahashi, Masayasu Oie, Yuetsu Tanaka, Fumitake Gejyo, Nobuyuki Tanaka, Kazuo Sugamura, Li Xie, Patrick L. Green, Masahiro Fujii
Virus-Cell Interactions
Glycosylation, Disulfide Bond Formation, and the Presence of a WSXWS-Like Motif in the Orf Virus GIF Protein Are Critical for Maintaining the Integrity of Binding to Ovine Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-2
C. J. McInnes, D. Deane, D. Haig, A. Percival, J. Thomson, A. R. Wood

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Interleukin-2

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