influenza B virus
Vaccines and Antiviral AgentsEffect of an Adenovirus-Vectored Universal Influenza Virus Vaccine on Pulmonary Pathophysiology in a Mouse ModelRespiratory viruses can emerge and spread rapidly before vaccines are available. It would be a tremendous advance to use vaccines that protect against whole categories of viruses, such as universal influenza vaccines, without the need to predict which virus will emerge.
Genetic Diversity and Evolution | SpotlightInfluenza B Viruses Exhibit Lower Within-Host Diversity than Influenza A Viruses in Human HostsThe evolution of influenza virus is a significant public health problem and necessitates the annual evaluation of influenza vaccine formulation to keep pace with viral escape from herd immunity. Influenza B virus is a serious health concern for children, in particular, yet remains understudied compared to influenza A virus. Influenza B virus evolves more slowly than influenza A virus, but the factors underlying this are not completely...
Virus-Cell InteractionsHemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human AirwaysInfluenza epidemics are caused by influenza A and influenza B viruses (IAV and IBV, respectively). IBV causes substantial disease; however, it is far less studied than IAV. While IAV originates from animal reservoirs, IBV circulates in humans only. Virus spread requires that the viral hemagglutinin (HA) is active and sufficiently stable in human airways. We resolve here how these mechanisms differ between IBV and IAV. Whereas human IAVs...
- Pathogenesis and ImmunityA Single Amino Acid in the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses
- Vaccines and Antiviral AgentsDevelopment of an Alternative Modified Live Influenza B Virus Vaccine
- Vaccines and Antiviral AgentsChimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model
- Pathogenesis and ImmunitySpecies-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 Protein
- Genetic Diversity and EvolutionMixed Infection and the Genesis of Influenza Virus Diversity
- Genome Replication and Regulation of Viral Gene ExpressionRegion Required for Protein Expression from the Stop-Start Pentanucleotide in the M Gene of Influenza B Virus