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influenza B virus

  • Influenza B Viruses Exhibit Lower Within-Host Diversity than Influenza A Viruses in Human Hosts
    Genetic Diversity and Evolution | Spotlight
    Influenza B Viruses Exhibit Lower Within-Host Diversity than Influenza A Viruses in Human Hosts

    The evolution of influenza virus is a significant public health problem and necessitates the annual evaluation of influenza vaccine formulation to keep pace with viral escape from herd immunity. Influenza B virus is a serious health concern for children, in particular, yet remains understudied compared to influenza A virus. Influenza B virus evolves more slowly than influenza A virus, but the factors underlying this are not completely...

    Andrew L. Valesano, William J. Fitzsimmons, John T. McCrone, Joshua G. Petrie, Arnold S. Monto, Emily T. Martin, Adam S. Lauring
  • Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways
    Virus-Cell Interactions
    Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways

    Influenza epidemics are caused by influenza A and influenza B viruses (IAV and IBV, respectively). IBV causes substantial disease; however, it is far less studied than IAV. While IAV originates from animal reservoirs, IBV circulates in humans only. Virus spread requires that the viral hemagglutinin (HA) is active and sufficiently stable in human airways. We resolve here how these mechanisms differ between IBV and IAV. Whereas human IAVs...

    Manon Laporte, Annelies Stevaert, Valerie Raeymaekers, Talitha Boogaerts, Inga Nehlmeier, Winston Chiu, Mohammed Benkheil, Bart Vanaudenaerde, Stefan Pöhlmann, Lieve Naesens
  • Open Access
    Pathogenesis and Immunity
    A Single Amino Acid in the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses
    Joon-Yong Bae, Ilseob Lee, Jin Il Kim, Sehee Park, Kirim Yoo, Miso Park, Gayeong Kim, Mee Sook Park, Joo-Yeon Lee, Chun Kang, Kisoon Kim, Man-Seong Park
  • Open Access
    Vaccines and Antiviral Agents
    Development of an Alternative Modified Live Influenza B Virus Vaccine
    Jefferson J. S. Santos, Courtney Finch, Troy Sutton, Adebimpe Obadan, Isabel Aguirre, Zhimin Wan, Diego Lopez, Ginger Geiger, Ana Silvia Gonzalez-Reiche, Lucas Ferreri, Daniel R. Perez
  • Vaccines and Antiviral Agents
    Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model
    Megan E. Ermler, Ericka Kirkpatrick, Weina Sun, Rong Hai, Fatima Amanat, Veronika Chromikova, Peter Palese, Florian Krammer
  • Pathogenesis and Immunity
    Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 Protein
    Gijs A. Versteeg, Benjamin G. Hale, Sander van Boheemen, Thorsten Wolff, Deborah J. Lenschow, Adolfo García-Sastre
  • Genetic Diversity and Evolution
    Mixed Infection and the Genesis of Influenza Virus Diversity
    Elodie Ghedin, Adam Fitch, Alex Boyne, Sara Griesemer, Jay DePasse, Jayati Bera, Xu Zhang, Rebecca A. Halpin, Marita Smit, Lance Jennings, Kirsten St. George, Edward C. Holmes, David J. Spiro
  • Genome Replication and Regulation of Viral Gene Expression
    Region Required for Protein Expression from the Stop-Start Pentanucleotide in the M Gene of Influenza B Virus
    Masato Hatta, Candice K. Kohlmeier, Yasuko Hatta, Makoto Ozawa, Yoshihiro Kawaoka
  • Pathogenesis and Immunity
    Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus Infection
    Caroline Lai, Jessica J. Struckhoff, Jana Schneider, Luis Martinez-Sobrido, Thorsten Wolff, Adolfo García-Sastre, Dong-Er Zhang, Deborah J. Lenschow
  • Virus-Cell Interactions
    Analysis of Influenza B Virus NS1 Protein Trafficking Reveals a Novel Interaction with Nuclear Speckle Domains
    Jana Schneider, Bianca Dauber, Krister Melén, Ilkka Julkunen, Thorsten Wolff

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