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HIV entry

  • GSK3732394: a Multi-specific Inhibitor of HIV Entry
    Vaccines and Antiviral Agents | Spotlight
    GSK3732394: a Multi-specific Inhibitor of HIV Entry

    There continue to be significant unmet medical needs for patients with HIV-1 infection. One way to improve adherence and decrease the likelihood of drug-drug interactions in HIV-1-infected patients is through the development of long-acting biologic inhibitors. Building on a bi-specific inhibitor approach targeting CD4 and gp41, a tri-specific molecule was generated with three distinct antiviral activities. The linkage of these three...

    David Wensel, Yongnian Sun, Jonathan Davis, Zhufang Li, Sharon Zhang, Thomas McDonagh, David Langley, Tracy Mitchell, Sebastien Tabruyn, Patrick Nef, Mark Cockett, Mark Krystal
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