herpesvirus latency

  • CD34<sup>+</sup> Hematopoietic Progenitor Cell Subsets Exhibit Differential Ability To Maintain Human Cytomegalovirus Latency and Persistence
    Virus-Cell Interactions
    CD34+ Hematopoietic Progenitor Cell Subsets Exhibit Differential Ability To Maintain Human Cytomegalovirus Latency and Persistence

    Human cytomegalovirus infection is associated with severe disease in transplant patients, and understanding how latency and reactivation occur in stem cell populations is essential to understand disease. CD34+ hematopoietic progenitor cells (HPCs) are a critical viral reservoir; however, these cells are a heterogeneous pool with donor-to-donor variation in functional, genetic, and phenotypic characteristics.

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    Lindsey B. Crawford, Meaghan H. Hancock, Hillary M. Struthers, Daniel N. Streblow, Andrew D. Yurochko, Patrizia Caposio, Felicia D. Goodrum, Jay A. Nelson
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