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herpes simplex

  • The XPO6 Exportin Mediates Herpes Simplex Virus 1 gM Nuclear Release Late in Infection
    Virus-Cell Interactions
    The XPO6 Exportin Mediates Herpes Simplex Virus 1 gM Nuclear Release Late in Infection

    The mechanisms that enable integral proteins to be targeted to the inner nuclear membrane are poorly understood. Herpes simplex virus 1 (HSV-1) glycoprotein M (gM) is an interesting candidate, as it is dynamically relocalized from nuclear envelopes to the trans-Golgi network (TGN) in a virus- and time-dependent fashion. However, it was, until now, unclear how gM was directed to the nucleus or evaded that compartment later on....

    Hugo Boruchowicz, Josiane Hawkins, Kendra Cruz-Palomar, Roger Lippé
  • Vaccines and Antiviral Agents
    Human Asymptomatic Epitope Peptide/CXCL10-Based Prime/Pull Vaccine Induces Herpes Simplex Virus-Specific Gamma Interferon-Positive CD107+ CD8+ T Cells That Infiltrate the Corneas and Trigeminal Ganglia of Humanized HLA Transgenic Rabbits and Protect against Ocular Herpes Challenge

    There is an urgent need for a vaccine against widespread herpes simplex virus infections. The present study demonstrates that immunization of HLA transgenic rabbits with a peptide/CXCL10 prime/pull vaccine triggered mobilization of HSV-specific CD8+ T cells locally into the cornea and TG, the sites of acute and latent herpesvirus infections, respectively. Mobilization of antiviral CD8+ T cells into the cornea and...

    Arif A. Khan, Ruchi Srivastava, Hawa Vahed, Soumyabrata Roy, Sager S. Walia, Grace J. Kim, Mona A. Fouladi, Taikun Yamada, Vincent T. Ly, Cynthia Lam, Anthony Lou, Vivianna Nguyen, Undariya Boldbaatar, Roger Geertsema, Nigel W. Fraser, Lbachir BenMohamed
  • Virus-Cell Interactions
    Mechanical Barriers Restrict Invasion of Herpes Simplex Virus 1 into Human Oral Mucosa
    Katharina Thier, Philipp Petermann, Elena Rahn, Daniel Rothamel, Wilhelm Bloch, Dagmar Knebel-Mörsdorf
  • Structure and Assembly
    The UL21 Tegument Protein of Herpes Simplex Virus 1 Is Differentially Required for the Syncytial Phenotype
    Akua Sarfo, Jason Starkey, Erica Mellinger, Dan Zhang, Pooja Chadha, Jillian Carmichael, John W. Wills
  • Virus-Cell Interactions
    Cysteines and N-Glycosylation Sites Conserved among All Alphaherpesviruses Regulate Membrane Fusion in Herpes Simplex Virus 1 Infection
    Paul J. F. Rider, Misagh Naderi, Scott Bergeron, Vladimir N. Chouljenko, Michal Brylinski, Konstantin G. Kousoulas
  • Pathogenesis and Immunity
    Selective Expression of CCR10 and CXCR3 by Circulating Human Herpes Simplex Virus-Specific CD8 T Cells
    Michael T. Hensel, Tao Peng, Anqi Cheng, Stephen C. De Rosa, Anna Wald, Kerry J. Laing, Lichen Jing, Lichun Dong, Amalia S. Magaret, David M. Koelle
  • Vaccines and Antiviral Agents
    Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1
    Kening Wang, Georgia D. Tomaras, Sinthujan Jegaskanda, M. Anthony Moody, Hua-Xin Liao, Kyle N. Goodman, Phillip W. Berman, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Jaranit Kaewkungwal, Barton F. Haynes, Jeffrey I. Cohen
  • Pathogenesis and Immunity
    CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8+ TEM and CD8+ TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease
    Ruchi Srivastava, Arif A. Khan, Sravya Chilukuri, Sabrina A. Syed, Tien T. Tran, Julie Furness, Elmostafa Bahraoui, Lbachir BenMohamed
  • Vaccines and Antiviral Agents
    Prophylactic Herpes Simplex Virus 2 (HSV-2) Vaccines Adjuvanted with Stable Emulsion and Toll-Like Receptor 9 Agonist Induce a Robust HSV-2-Specific Cell-Mediated Immune Response, Protect against Symptomatic Disease, and Reduce the Latent Viral Reservoir
    Michael T. Hensel, Jason D. Marshall, Michael R. Dorwart, Darren S. Heeke, Eileen Rao, Padmaja Tummala, Li Yu, Gary H. Cohen, Roselyn J. Eisenberg, Derek D. Sloan
  • Vaccines and Antiviral Agents
    Impact of Type I Interferon on the Safety and Immunogenicity of an Experimental Live-Attenuated Herpes Simplex Virus 1 Vaccine in Mice
    Derek J. Royer, Meghan M. Carr, Ana J. Chucair-Elliott, William P. Halford, Daniel J. J. Carr

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