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gp120

  • SERINC5 Inhibits HIV-1 Infectivity by Altering the Conformation of gp120 on HIV-1 Particles
    Virus-Cell Interactions
    SERINC5 Inhibits HIV-1 Infectivity by Altering the Conformation of gp120 on HIV-1 Particles

    SERINC5 is a host cell protein that inhibits the infectivity of HIV-1 by a novel and poorly understood mechanism. Here, we provide evidence that the SERINC5 protein alters the conformation of the HIV-1 Env proteins and that this action is correlated with SERINC5’s ability to inhibit HIV-1 infectivity. Defining the specific effects of SERINC5 on the HIV-1 glycoprotein conformation may be useful for designing new antiviral strategies...

    Austin Featherstone, Christopher Aiken
  • Open Access
    Glycan Profiles of gp120 Protein Vaccines from Four Major HIV-1 Subtypes Produced from Different Host Cell Lines under Non-GMP or GMP Conditions
    Vaccines and Antiviral Agents
    Glycan Profiles of gp120 Protein Vaccines from Four Major HIV-1 Subtypes Produced from Different Host Cell Lines under Non-GMP or GMP Conditions

    HIV-1 Env protein is a major target for the development of an HIV-1 vaccine. Env is covered with a large number of sugar-based glycan forms; about 50% of the Env molecular weight is composed of glycans. Glycan analysis of recombinant Env is important for understanding its roles in viral pathogenesis and immune responses. The current report presents the first extensive comparison of glycosylation patterns of recombinant gp120 proteins...

    Shixia Wang, Yegor Voronin, Peng Zhao, Mayumi Ishihara, Nickita Mehta, Mindy Porterfield, Yuxin Chen, Christopher Bartley, Guangnan Hu, Dong Han, Lance Wells, Michael Tiemeyer, Shan Lu
  • Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection
    Structure and Assembly
    Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection
    Kun-Wei Chan, Ruimin Pan, Matthew Costa, Miroslaw K. Gorny, Shixia Wang, Shan Lu, Xiang-Peng Kong
  • Open Access
    Virus-Cell Interactions
    HIV-1 gp41 Residues Modulate CD4-Induced Conformational Changes in the Envelope Glycoprotein and Evolution of a Relaxed Conformation of gp120

    Binding of the HIV envelope glycoprotein (Env) to cellular CD4 and chemokine receptors triggers conformational changes in Env that mediate virus entry, but premature triggering of Env conformational changes leads to virus inactivation. Currently, we have a limited understanding of the network of residues that regulate Env conformational changes. Here, we identify residues in HR1 of gp41 that modulate conformational changes in response...

    Paul W. Keller, Orrianne Morrison, Russell Vassell, Carol D. Weiss
  • Open Access
    Virus-Cell Interactions
    Incomplete Downregulation of CD4 Expression Affects HIV-1 Env Conformation and Antibody-Dependent Cellular Cytotoxicity Responses
    Jérémie Prévost, Jonathan Richard, Halima Medjahed, Audrey Alexander, Jennifer Jones, John C. Kappes, Christina Ochsenbauer, Andrés Finzi
  • Vaccines and Antiviral Agents | Spotlight
    Reduced Cell-Associated DNA and Improved Viral Control in Macaques following Passive Transfer of a Single Anti-V2 Monoclonal Antibody and Repeated Simian/Human Immunodeficiency Virus Challenges
    Ann J. Hessell, Mariya B. Shapiro, Rebecca Powell, Delphine C. Malherbe, Sean P. McBurney, Shilpi Pandey, Tracy Cheever, William F. Sutton, Christoph Kahl, Byung Park, Susan Zolla-Pazner, Nancy L. Haigwood
  • Structure and Assembly | Spotlight
    Increased Epitope Complexity Correlated with Antibody Affinity Maturation and a Novel Binding Mode Revealed by Structures of Rabbit Antibodies against the Third Variable Loop (V3) of HIV-1 gp120
    Ruimin Pan, Yali Qin, Marisa Banasik, William Lees, Adrian J. Shepherd, Michael W. Cho, Xiang-Peng Kong
  • Open Access
    Vaccines and Antiviral Agents
    A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques
    Andrew T. Jones, Venkateswarlu Chamcha, Sannula Kesavardhana, Xiaoying Shen, David Beaumont, Raksha Das, Linda S. Wyatt, Celia C. LaBranche, Sherry Stanfield-Oakley, Guido Ferrari, David C. Montefiori, Bernard Moss, Georgia D. Tomaras, Raghavan Varadarajan, Rama Rao Amara
  • Pathogenesis and Immunity
    Identification of Novel Structural Determinants in MW965 Env That Regulate the Neutralization Phenotype and Conformational Masking Potential of Primary HIV-1 Isolates
    Zakiya M. Qualls, Alok Choudhary, William Honnen, Raja Prattipati, James E. Robinson, Abraham Pinter
  • Vaccines and Antiviral Agents
    Functional Stability of HIV-1 Envelope Trimer Affects Accessibility to Broadly Neutralizing Antibodies at Its Apex
    Syna Kuriakose Gift, Daniel P. Leaman, Lei Zhang, Arthur S. Kim, Michael B. Zwick

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