epithelial cells
Cellular Response to InfectionDUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1β SignalingRhinoviruses are one of the causes of the common cold. In patients with asthma or chronic obstructive pulmonary disease, viral infections, including those with rhinovirus, are the commonest cause of exacerbations. Novel therapeutics to limit viral inflammation are clearly required. The work presented here identifies DUSP10 as an important protein involved in limiting the inflammatory response in the airway without affecting immune...
Virus-Cell Interactionsαvβ3 Integrin Is Required for Efficient Infection of Epithelial Cells with Human Adenovirus Type 26Adenovirus-based vectors are used today for gene transfer and vaccination. HAdV26 has emerged as a promising candidate vector for development of vaccines due to its relatively low seroprevalence and its ability to induce potent immune responses against inserted transgenes. However, data regarding the basic biology of the virus, like receptor usage or intracellular trafficking, are limited. In this work, we found that efficient infection...