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endothelial cells

  • Kaposi's Sarcoma-Associated Herpesvirus MicroRNA Mutants Modulate Cancer Hallmark Phenotypic Differences in Human Endothelial Cells
    Editor's Pick Transformation and Oncogenesis
    Kaposi's Sarcoma-Associated Herpesvirus MicroRNA Mutants Modulate Cancer Hallmark Phenotypic Differences in Human Endothelial Cells

    Kaposi’s sarcoma-associated herpesvirus (KSHV) causes Kaposi’s sarcoma (KS). The contribution of KSHV microRNAs (miRNAs) to oncogenesis is not fully understood.

    Lauren A. Gay, Daniel Stribling, Peter C. Turner, Rolf Renne
  • NS5 Sumoylation Directs Nuclear Responses That Permit Zika Virus To Persistently Infect Human Brain Microvascular Endothelial Cells
    Virus-Cell Interactions | Spotlight
    NS5 Sumoylation Directs Nuclear Responses That Permit Zika Virus To Persistently Infect Human Brain Microvascular Endothelial Cells

    ZIKV is a unique neurovirulent flavivirus that persistently infects human brain microvascular endothelial cells (hBMECs), the primary barrier that restricts viral access to neuronal compartments. Here, we demonstrate that flavivirus-specific SIM and SUMO sites determine the assembly of NS5 proteins into discrete nuclear bodies (NBs). We found that NS5 SIM sites are required for NS5 nuclear localization and that SUMO sites regulate NS5...

    Jonas N. Conde, William R. Schutt, Megan Mladinich, Sook-Young Sohn, Patrick Hearing, Erich R. Mackow
  • Kaposi’s Sarcoma-Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells
    Virus-Cell Interactions
    Kaposi’s Sarcoma-Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells

    Kaposi’s sarcoma-associated herpesvirus (KSHV) manipulates several cellular pathways for its survival advantage during its latency in the infected human host. Here, we demonstrate that KSHV infection upregulates the expression of genes related to neuronal and neuroendocrine (NE) functions that are characteristic of NE tumors, both in vitro and in KS patient tissues and the heterogeneity of neuroendocrine receptors having...

    Mohanan Valiya Veettil, Gayathri Krishna, Arunava Roy, Anandita Ghosh, Dipanjan Dutta, Binod Kumar, Sayan Chakraborty, Thoppil Raveendran Anju, Neelam Sharma-Walia, Bala Chandran
  • Free
    Vaccines and Antiviral Agents
    Suppression of Zika Virus Infection and Replication in Endothelial Cells and Astrocytes by PKA Inhibitor PKI 14-22
    Fan Cheng, Suzane Ramos da Silva, I-Chueh Huang, Jae U. Jung, Shou-Jiang Gao
  • Virus-Cell Interactions
    Role of Autophagy in HIV-1 Matrix Protein p17-Driven Lymphangiogenesis
    Pietro Mazzuca, Stefania Marsico, Kai Schulze, Stefania Mitola, Marina C. Pils, Cinzia Giagulli, Carlos A. Guzman, Arnaldo Caruso, Francesca Caccuri
  • Virus-Cell Interactions | Spotlight
    Loss of the Human Cytomegalovirus US16 Protein Abrogates Virus Entry into Endothelial and Epithelial Cells by Reducing the Virion Content of the Pentamer
    Anna Luganini, Noemi Cavaletto, Stefania Raimondo, Stefano Geuna, Giorgio Gribaudo
  • Pathogenesis and Immunity | Spotlight
    Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1
    Shanna L. Ashley, Carla D. Pretto, Matthew T. Stier, Padma Kadiyala, Luiza Castro-Jorge, Tien-Huei Hsu, Robert Doherty, Kelly E. Carnahan, Maria G. Castro, Pedro R. Lowenstein, Katherine R. Spindler
  • Virus-Cell Interactions
    VP23R of Infectious Spleen and Kidney Necrosis Virus Mediates Formation of Virus-Mock Basement Membrane To Provide Attaching Sites for Lymphatic Endothelial Cells
    Xiaopeng Xu, Shaoping Weng, Ting Lin, Junliang Tang, Lichao Huang, Jing Wang, Xiaoqiang Yu, Ling Lu, Zhijian Huang, Jianguo He
  • Virus-Cell Interactions
    Andes Virus Regulation of Cellular MicroRNAs Contributes to Hantavirus-Induced Endothelial Cell Permeability
    Timothy Pepini, Elena E. Gorbunova, Irina N. Gavrilovskaya, Jonathan E. Mackow, Erich R. Mackow
  • Virus-Cell Interactions
    Andes Virus Disrupts the Endothelial Cell Barrier by Induction of Vascular Endothelial Growth Factor and Downregulation of VE-Cadherin
    Punya Shrivastava-Ranjan, Pierre E. Rollin, Christina F. Spiropoulou

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