encephalitis
Pathogenesis and Immunity | SpotlightCD4 T Cells, CD8 T Cells, and Monocytes Coordinate To Prevent Rift Valley Fever Virus EncephalitisRVFV is found in Africa and the Middle East and is transmitted by mosquitos or through contact with infected animals. Infected individuals can develop mild disease or more severe forms, such as hepatitis or encephalitis. In order to understand why some individuals develop encephalitis, we first need to know which immune functions protect those who do not develop this form of disease. In this study, we used a mouse model of RVFV...
Pathogenesis and ImmunityReovirus Neurotropism and Virulence Are Dictated by Sequences in the Head Domain of the Viral Attachment ProteinViral encephalitis is a serious and often life-threatening inflammation of the brain. Mammalian orthoreoviruses are promising oncolytic therapeutics for humans but establish virulent, serotype-dependent disease in the central nervous system (CNS) of many young mammals. Serotype 1 reoviruses infect ependymal cells and produce hydrocephalus, whereas serotype 3 reoviruses infect neurons and cause encephalitis. Reovirus neurotropism is...
- Virus-Cell Interactions | SpotlightAxonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43
Coronaviruses may invade the CNS, disseminate, and participate in the induction of neurological diseases. Their neuropathogenicity is being increasingly recognized in humans, and the presence and persistence of human coronaviruses (HCoV) in human brains have been proposed to cause long-term sequelae. Using our mouse model relying on natural susceptibility to HCoV OC43 and neuronal cell cultures, we have defined the most relevant path...
- Pathogenesis and ImmunityPharmacologic Depletion of Microglia Increases Viral Load in the Brain and Enhances Mortality in Murine Models of Flavivirus-Induced Encephalitis
As CNS invasion by flaviviruses is a rare but life-threatening event, it is critical to understand how brain-resident immune cells elicit protection or injury during disease progression. Microglia have been shown to be important in viral clearance but may also contribute to CNS injury as part of the neuroinflammatory process. By utilizing a microglial depletion model, we can begin to parse out the exact roles of microglia during...
- Pathogenesis and ImmunityInterleukin-10 Modulation of Virus Clearance and Disease in Mice with Alphaviral Encephalomyelitis
- Pathogenesis and ImmunityPeripheral Blood Biomarkers of Disease Outcome in a Monkey Model of Rift Valley Fever Encephalitis
- Pathogenesis and Immunity | SpotlightMurine Olfactory Bulb Interneurons Survive Infection with a Neurotropic Coronavirus
- Virus-Cell Interactions | SpotlightPropagation of Astrovirus VA1, a Neurotropic Human Astrovirus, in Cell Culture
- Pathogenesis and Immunity | SpotlightMatrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1
- Pathogenesis and ImmunityA Protective Role for Interleukin-1 Signaling during Mouse Adenovirus Type 1-Induced Encephalitis