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ebolavirus

  • Arbidol and Other Low-Molecular-Weight Drugs That Inhibit Lassa and Ebola Viruses
    Vaccines and Antiviral Agents
    Arbidol and Other Low-Molecular-Weight Drugs That Inhibit Lassa and Ebola Viruses

    Lassa and Ebola viruses continue to cause severe outbreaks in humans, yet there are only limited therapeutic options to treat the deadly hemorrhagic fever diseases they cause. Because of overlapping geographic occurrences and similarities in mode of entry into cells, we seek a practical drug or drug cocktail that could be used to treat infections by both viruses. Toward this goal, we directly compared eight drugs, approved or in...

    C. E. Hulseberg, L. Fénéant, K. M. Szymańska-de Wijs, N. P. Kessler, E. A. Nelson, C. J. Shoemaker, C. S. Schmaljohn, S. J. Polyak, J. M. White
  • Free
    Cellular Response to Infection
    Comparative Transcriptomics Highlights the Role of the Activator Protein 1 Transcription Factor in the Host Response to Ebolavirus
    James W. Wynne, Shawn Todd, Victoria Boyd, Mary Tachedjian, Reuben Klein, Brian Shiell, Megan Dearnley, Alexander J. McAuley, Amanda P. Woon, Anthony W. Purcell, Glenn A. Marsh, Michelle L. Baker
  • Free
    Virus-Cell Interactions
    Cooperation of the Ebola Virus Proteins VP40 and GP1,2 with BST2 To Activate NF-κB Independently of Virus-Like Particle Trapping
    Maryan G. Rizk, Christopher F. Basler, John Guatelli
  • Free
    Virus-Cell Interactions
    Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress
    Ziying Han, Cari A. Sagum, Fumio Takizawa, Gordon Ruthel, Corbett T. Berry, Jing Kong, J. Oriol Sunyer, Bruce D. Freedman, Mark T. Bedford, Sachdev S. Sidhu, Marius Sudol, Ronald N. Harty
  • Free
    Virus-Cell Interactions
    The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication
    Preeti Bharaj, Colm Atkins, Priya Luthra, Maria Isabel Giraldo, Brian E. Dawes, Lisa Miorin, Jeffrey R. Johnson, Nevan J. Krogan, Christopher F. Basler, Alexander N. Freiberg, Ricardo Rajsbaum
  • Free
    Vaccines and Antiviral Agents
    Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model
    James Duehr, Teddy John Wohlbold, Lisa Oestereich, Veronika Chromikova, Fatima Amanat, Madhusudan Rajendran, Sergio Gomez-Medina, Ignacio Mena, Benjamin R. tenOever, Adolfo García-Sastre, Christopher F. Basler, Cesar Munoz-Fontela, Florian Krammer
  • Free
    Virus-Cell Interactions
    Spontaneous Mutation at Amino Acid 544 of the Ebola Virus Glycoprotein Potentiates Virus Entry and Selection in Tissue Culture
    John B. Ruedas, Jason T. Ladner, Chelsea R. Ettinger, Suryaram Gummuluru, Gustavo Palacios, John H. Connor
  • Free
    Vaccines and Antiviral Agents
    Recombinant Modified Vaccinia Virus Ankara Generating Ebola Virus-Like Particles
    Marc Schweneker, Andrea S. Laimbacher, Gert Zimmer, Susanne Wagner, Elisabeth M. Schraner, Michael Wolferstätter, Marieken Klingenberg, Ulrike Dirmeier, Robin Steigerwald, Henning Lauterbach, Hubertus Hochrein, Paul Chaplin, Mark Suter, Jürgen Hausmann
  • Free
    Cellular Response to Infection | Spotlight
    Ebolaviruses Associated with Differential Pathogenicity Induce Distinct Host Responses in Human Macrophages
    Judith Olejnik, Adriana Forero, Laure R. Deflubé, Adam J. Hume, Whitney A. Manhart, Andrew Nishida, Andrea Marzi, Michael G. Katze, Hideki Ebihara, Angela L. Rasmussen, Elke Mühlberger
  • Free
    Vaccines and Antiviral Agents
    Attenuated Human Parainfluenza Virus Type 1 Expressing Ebola Virus Glycoprotein GP Administered Intranasally Is Immunogenic in African Green Monkeys
    Matthias Lingemann, Xueqiao Liu, Sonja Surman, Bo Liang, Richard Herbert, Ashley D. Hackenberg, Ursula J. Buchholz, Peter L. Collins, Shirin Munir

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