E1A
Vaccines and Antiviral AgentsInhibition of Human Adenovirus Replication by the Importin α/β1 Nuclear Import Inhibitor IvermectinHuman adenoviruses (HAdVs) represent a ubiquitous and clinically important pathogen without an effective antiviral treatment. HAdV infections typically cause mild symptoms; however, individuals such as children, those with underlying conditions, and those with compromised immune systems can develop severe disseminated disease. Our results demonstrate that ivermectin, an FDA-approved antiparasitic agent, is effective at inhibiting...
Genome Replication and Regulation of Viral Gene ExpressionAdenovirus 5 E1A Interacts with E4orf3 To Regulate Viral Chromatin OrganizationTo successfully replicate, human adenovirus needs to carry out a rapid yet ordered transcriptional program that executes and drives viral replication. Early in infection, the viral E1A proteins are the key activators and regulators of viral transcription. Here we report, for the first time, that E1A works together with E4orf3 to perfect the viral transcriptional program and identify a novel mechanism by which the virus can adjust viral...
- Virus-Cell InteractionsAdenovirus 5 E1A-Mediated Suppression of p53 via FUBP1
- Virus-Cell InteractionsSuppression of Type I Interferon Signaling by E1A via RuvBL1/Pontin
- Transformation and OncogenesisEfficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes