dissemination
Pathogenesis and Immunity | SpotlightLymphatic Type 1 Interferon Responses Are Critical for Control of Systemic Reovirus DisseminationType 1 interferons (IFN-1) are critical host responses to viral infection. However, the contribution of IFN-1 responses to control of viruses in specific cell and tissue types is not fully defined.
Genetic Diversity and Evolution | SpotlightRapid Dissemination and Monopolization of Viral Populations in Mice Revealed Using a Panel of Barcoded VirusesEnteric viruses initiate infection in the gastrointestinal tract but can disseminate to systemic sites. However, the dynamics of viral dissemination are unclear. In this study, we created a library of 135 barcoded coxsackieviruses to examine viral population diversity across time and space following oral inoculation of mice. Overall, we found that the broad population of viruses disseminates early, followed by monopolization of mouse...
Pathogenesis and Immunity | SpotlightMurine Cytomegalovirus Glycoprotein O Promotes Epithelial Cell Infection In VivoHuman cytomegalovirus is a leading cause of congenital disease. This reflects its capacity for systemic spread. A vaccine is needed, but the best viral targets are unclear. Attention has focused on the virion membrane fusion complex. It has 2 forms, so we need to know what each contributes to host colonization. One includes the virion glycoprotein O. We used murine cytomegalovirus, which has equivalent fusion complexes, to determine the...
- Genome Replication and Regulation of Viral Gene Expression | SpotlightNonstructural Protein σ1s Is Required for Optimal Reovirus Protein Expression
- Virus-Cell InteractionsCoxsackievirus B Escapes the Infected Cell in Ejected Mitophagosomes