cyclophilin A
Genome Replication and Regulation of Viral Gene ExpressionISGylation of Hepatitis C Virus NS5A Protein Promotes Viral RNA Replication via Recruitment of Cyclophilin AHost cells have evolved host defense machinery (such as innate immunity) to eliminate viral infections. Viruses have evolved several counteracting strategies for achieving an immune escape from host defense machinery, including type I interferons (IFNs) and inflammatory cytokines. ISG15 is an IFN-inducible ubiquitin-like protein that is covalently conjugated to the viral protein via specific Lys residues and suppresses viral functions...
Virus-Cell InteractionsCA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity PhenotypesThe specific mechanisms by which HIV-1 infects nondividing cells are unclear. A mutation in the HIV-1 capsid protein abolishes the ability of the virus to infect nondividing cells, serving as a tool to examine cell cycle dependence of HIV-1 infection. We have shown that two widely used HIV-1 molecular clones exhibit significantly different N57A infectivity phenotypes due to fewer than a handful of CA amino acid differences and that...
- Virus-Cell InteractionsPotent Lentiviral Restriction by a Synthetic Feline TRIM5 Cyclophilin A Fusion
- Virus-Cell InteractionsRole of Human Immunodeficiency Virus Type 1 Integrase in Uncoating of the Viral Core