coronavirus
Virus-Cell InteractionsPotential Differences in Cleavage of the S Protein and Type 1 Interferon Together Control Human Coronavirus Infection, Propagation, and Neuropathology within the Central Nervous SystemHuman coronaviruses (HCoV) are recognized respiratory pathogens. The emergence of the novel pathogenic member of this family in December 2019 (SARS-CoV-2, which causes COVID-19) poses a global health emergency.
Vaccines and Antiviral AgentsInsight into Vaccine Development for Alphacoronaviruses Based on Structural and Immunological Analyses of Spike ProteinsOutbreaks of coronaviruses, especially SARS-CoV-2, pose a serious threat to global public health. Development of vaccines to prevent the coronaviruses that can infect humans has always been a top priority.
Virus-Cell InteractionsGeneration and Characterization of Recombinant SARS-CoV-2 Expressing Reporter GenesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen that causes coronavirus disease 2019 (COVID-19), has significantly impacted the human health and economic status worldwide. There is an urgent need to identify effective prophylactics and therapeutics for the treatment of SARS-CoV-2 infection and associated COVID-19.
Virus-Cell InteractionsSpike Glycoprotein and Host Cell Determinants of SARS-CoV-2 Entry and Cytopathic EffectsThe development of an effective and durable SARS-CoV-2 vaccine is essential for combating the growing COVID-19 pandemic. The SARS-CoV-2 spike (S) glycoprotein is the main target of neutralizing antibodies elicited during virus infection or following vaccination.
Virus-Cell InteractionsA Gammacoronavirus, Avian Infectious Bronchitis Virus, and an Alphacoronavirus, Porcine Epidemic Diarrhea Virus, Exploit a Cell Survival Strategy by Upregulating cFOS To Promote Virus ReplicationThe ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by a newly emerged zoonotic coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]), highlights the importance of coronaviruses as human and animal pathogens and our knowledge gaps in understanding the cellular mechanisms, especially the mechanisms shared among human and animal coronaviruses, exploited by coronaviruses for optimal replication and...
Vaccines and Antiviral AgentsHTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoVThe beginning of 2020 brought us information about the novel coronavirus emerging in China. Rapid research resulted in the characterization of the pathogen, which appeared to be a member of the SARS-like cluster, commonly seen in bats.
Structure and AssemblyStructure of Nonstructural Protein 1 from SARS-CoV-2Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 pandemic. One protein known to play a critical role in the coronavirus life cycle is nonstructural protein 1 (nsp1).
Vaccines and Antiviral AgentsEffective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin DerivativesThe emergence of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in Wuhan, China, in late 2019 and its subsequent spread to the rest of the world has created a pandemic situation unprecedented in modern history. While ACE2 has been identified as the viral receptor, cellular polysaccharides have also been implicated in virus entry.
Pathogenesis and ImmunityMiddle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in MiceMiddle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus causing human infections with high mortality rate (∼35%). Animal models together with reverse-genetics systems are essential to understand MERS-CoV pathogenesis. We developed a reverse-genetics system for a mouse-adapted MERS-CoV that reproduces the virus behavior observed in humans. This system is highly useful to investigate the role of specific viral genes in...
Structure and AssemblyThe SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-RibosylhydrolaseSARS-CoV-2 has recently emerged into the human population and has led to a worldwide pandemic of COVID-19 that has caused more than 1.2 million deaths worldwide. With no currently approved treatments, novel therapeutic strategies are desperately needed.