CD4-induced antibodies

  • Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation
    Pathogenesis and Immunity
    Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation

    Stabilization of HIV-1 Env state 2A has been shown to sensitize infected cells to ADCC. State 2A can be stabilized by a “cocktail” composed of CD4mc, anti-CoRBS, and anti-cluster A Abs.

    Dani Vézina, Shang Yu Gong, William D. Tolbert, Shilei Ding, Dung Nguyen, Jonathan Richard, Gabrielle Gendron-Lepage, Bruno Melillo, Amos B. Smith, Marzena Pazgier, Andrés Finzi
  • CD4 Incorporation into HIV-1 Viral Particles Exposes Envelope Epitopes Recognized by CD4-Induced Antibodies
    Pathogenesis and Immunity
    CD4 Incorporation into HIV-1 Viral Particles Exposes Envelope Epitopes Recognized by CD4-Induced Antibodies

    It has been well established that Env-CD4 complexes expose epitopes recognized by commonly elicited CD4-induced antibodies at the surface of HIV-1-infected cells, rendering them vulnerable to ADCC responses. Here, we show that CD4 incorporation has a profound impact on Env conformation at the surface of viral particles. Incorporated CD4 exposes CD4-induced epitopes on Env, rendering HIV-1 susceptible to neutralization by otherwise...

    Shilei Ding, Romain Gasser, Gabrielle Gendron-Lepage, Halima Medjahed, William D. Tolbert, Joseph Sodroski, Marzena Pazgier, Andrés Finzi
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