attenuation
Vaccines and Antiviral Agents | SpotlightAn E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for MiceTick-borne encephalitis virus (TBEV) is a pathogen that causes severe human neuroinfections in Europe and Asia and for which there is currently no specific therapy. We have previously found that galidesivir (BCX4430), a broad-spectrum RNA virus inhibitor, which is under clinical development for treatment of Ebola and yellow fever virus infections, has a strong antiviral effect against TBEV. For any antiviral drug, it is important to...
Genetic Diversity and EvolutionAttenuation of Infectious Bronchitis Virus in Eggs Results in Different Patterns of Genomic Variation across Multiple ReplicatesInfectious bronchitis remains a major problem in the global poultry industry, despite the existence of many different vaccines. IBV vaccines are currently developed by serial passage of a virulent strain on embryonated hen’s eggs until attenuation; however, little is known about the evolution of the viral population during the process of attenuation. High-throughput sequencing of four replicates of a serially egg-passaged IBV revealed a...
- Pathogenesis and ImmunityAttenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques
- Vaccines and Antiviral Agents | SpotlightSingle-Dose Trivalent VesiculoVax Vaccine Protects Macaques from Lethal Ebolavirus and Marburgvirus Challenge
- Pathogenesis and Immunity | SpotlightZika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated and Defective in Neuroinvasion