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astrocytes

  • JC Polyomavirus Infection Reveals Delayed Progression of the Infectious Cycle in Normal Human Astrocytes
    Virus-Cell Interactions
    JC Polyomavirus Infection Reveals Delayed Progression of the Infectious Cycle in Normal Human Astrocytes

    Animal models are crucial in advancing biomedical research and defining the pathogenesis of human disease. Unfortunately, not all diseases can be easily modeled in a nonhuman host or such models are cost prohibitive to generate, including models for the human-specific virus JC polyomavirus (JCPyV). JCPyV infects most of the population but can cause a rare, fatal disease, progressive multifocal leukoencephalopathy (PML). There have been...

    Michael P. Wilczek, Jeanne K. DuShane, Francesca J. Armstrong, Melissa S. Maginnis
  • Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids
    Virus-Cell Interactions | Spotlight
    Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids

    Human cytomegalovirus (HCMV) replicates in several cell types throughout the body, causing disease in the absence of an effective immune response. Studies on HCMV require cultured human cells and tissues due to species specificity. In these studies, we investigated the impact of infection on developing three-dimensional cortical organoid tissues, with specific emphasis on cell-type-dependent calcium signaling. Calcium signaling is an...

    Samantha L. Sison, Benjamin S. O’Brien, Amanda J. Johnson, Emily R. Seminary, Scott S. Terhune, Allison D. Ebert
  • Open Access
    Cellular Response to Infection
    Alpha/Beta Interferon (IFN-α/β) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-γ-Dependent Responses
    Mihyun Hwang, Cornelia C. Bergmann
  • Free
    Vaccines and Antiviral Agents
    Suppression of Zika Virus Infection and Replication in Endothelial Cells and Astrocytes by PKA Inhibitor PKI 14-22
    Fan Cheng, Suzane Ramos da Silva, I-Chueh Huang, Jae U. Jung, Shou-Jiang Gao
  • Pathogenesis and Immunity | Spotlight
    Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1
    Shanna L. Ashley, Carla D. Pretto, Matthew T. Stier, Padma Kadiyala, Luiza Castro-Jorge, Tien-Huei Hsu, Robert Doherty, Kelly E. Carnahan, Maria G. Castro, Pedro R. Lowenstein, Katherine R. Spindler
  • Virus-Cell Interactions
    Regulation of Proinflammatory Cytokine Expression in Primary Mouse Astrocytes by Coronavirus Infection
    Dongdong Yu, Hongqing Zhu, Yin Liu, Jianzhong Cao, Xuming Zhang
  • Pathogenesis and Immunity
    Increased In Vivo Activation of Microglia and Astrocytes in the Brains of Mice Transgenic for an Infectious R5 Human Immunodeficiency Virus Type 1 Provirus and for CD4-Specific Expression of Human Cyclin T1 in Response to Stimulation by Lipopolysaccharides
    Jinglin Sun, Jian Hua Zheng, Mengliang Zhao, Sunhee Lee, Harris Goldstein
  • Pathogenesis and Immunity
    Prion Protein Expression Differences in Microglia and Astroglia Influence Scrapie-Induced Neurodegeneration in the Retina and Brain of Transgenic Mice
    Lisa Kercher, Cynthia Favara, James F. Striebel, Rachel LaCasse, Bruce Chesebro
  • Cellular Response to Infection
    Astrocyte Indoleamine 2,3-Dioxygenase Is Induced by the TLR3 Ligand Poly(I:C): Mechanism of Induction and Role in Antiviral Response
    Hyeon-Sook Suh, Meng-Liang Zhao, Mark Rivieccio, Shinyeop Choi, Erin Connolly, Yongmei Zhao, Osamu Takikawa, Celia F. Brosnan, Sunhee C. Lee
  • Cellular Response to Infection | Spotlight
    Bystander Attenuation of Neuronal and Astrocyte Intercellular Communication by Murine Cytomegalovirus Infection of Glia
    Winson S. C. Ho, Anthony N. van den Pol

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