astrocytes
- Virus-Cell InteractionsJC Polyomavirus Infection Reveals Delayed Progression of the Infectious Cycle in Normal Human Astrocytes
Animal models are crucial in advancing biomedical research and defining the pathogenesis of human disease. Unfortunately, not all diseases can be easily modeled in a nonhuman host or such models are cost prohibitive to generate, including models for the human-specific virus JC polyomavirus (JCPyV). JCPyV infects most of the population but can cause a rare, fatal disease, progressive multifocal leukoencephalopathy (PML). There have been...
- Virus-Cell Interactions | SpotlightHuman Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids
Human cytomegalovirus (HCMV) replicates in several cell types throughout the body, causing disease in the absence of an effective immune response. Studies on HCMV require cultured human cells and tissues due to species specificity. In these studies, we investigated the impact of infection on developing three-dimensional cortical organoid tissues, with specific emphasis on cell-type-dependent calcium signaling. Calcium signaling is an...
- Vaccines and Antiviral AgentsSuppression of Zika Virus Infection and Replication in Endothelial Cells and Astrocytes by PKA Inhibitor PKI 14-22
- Pathogenesis and Immunity | SpotlightMatrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1
- Cellular Response to Infection | SpotlightBystander Attenuation of Neuronal and Astrocyte Intercellular Communication by Murine Cytomegalovirus Infection of Glia