antiviral immunity
Cellular Response to InfectionMicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2
Pathogenesis and ImmunityPhosphatase Cdc25A Negatively Regulates the Antiviral Immune Response by Inhibiting TBK1 Activity- Virus-Cell InteractionsLnc-ISG20 Inhibits Influenza A Virus Replication by Enhancing ISG20 Expression
The replication of influenza A virus is regulated by host factors. However, the mechanisms by which lncRNAs regulate IAV infection are not well understood. We identified that lnc-ISG20 is upregulated during IAV infection and is also an interferon-stimulated gene. We demonstrated that lnc-ISG20 can enhance ISG20 expression, which in turn inhibits IAV replication. Our studies indicate that lnc-ISG20 functions as a competing endogenous RNA...
- Cellular Response to InfectionDefining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS