antigen-presenting cells
Cellular Response to InfectionHerpes Simplex Virus 1 ICP22 Suppresses CD80 Expression by Murine Dendritic CellsHSV-1-induced eye disease is a major public health problem. Eye disease is associated closely with immune responses to the virus and is exacerbated by delayed clearance of the primary infection. The immune system relies on antigen-presenting cells of the innate immune system to activate the T cell response. We found that HSV-1 utilizes a robust and finely targeted mechanism of local immune evasion. It downregulates the expression of the...
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