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amino acid substitution

  • Basic Amino Acid Substitution at Residue 367 of the Envelope Protein of Tembusu Virus Plays a Critical Role in Pathogenesis
    Pathogenesis and Immunity
    Basic Amino Acid Substitution at Residue 367 of the Envelope Protein of Tembusu Virus Plays a Critical Role in Pathogenesis

    Outbreaks of Tembusu virus (TMUV) infection have caused huge economic losses in the production of domestic waterfowl since the virus was first recognized in China in 2010. To control TMUV infection, a live-attenuated vaccine candidate of TMUV was developed in our previous study, but the mechanisms of virulence attenuation are not fully understood. Here, we found that the Thr-to-Lys substitution at E367 is a crucial determinant of TMUV...

    Mengxu Sun, Lijiao Zhang, Yanxin Cao, Jun Wang, Ziding Yu, Xue Sun, Fengli Liu, Zhuolin Li, Pinghuang Liu, Jingliang Su
  • Vaccines and Antiviral Agents
    High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers
    Jonathan T. Sullivan, Chidananda Sulli, Alberto Nilo, Anila Yasmeen, Gabriel Ozorowski, Rogier W. Sanders, Andrew B. Ward, P. J. Klasse, John P. Moore, Benjamin J. Doranz
  • Open Access
    Vaccines and Antiviral Agents
    Foot-and-Mouth Disease (FMD) Virus 3C Protease Mutant L127P: Implications for FMD Vaccine Development
    Michael Puckette, Benjamin A. Clark, Justin D. Smith, Traci Turecek, Erica Martel, Lindsay Gabbert, Melia Pisano, William Hurtle, Juan M. Pacheco, José Barrera, John G. Neilan, Max Rasmussen
  • Prions
    Effect of Polymorphisms at Codon 146 of the Goat PRNP Gene on Susceptibility to Challenge with Classical Scrapie by Different Routes
    Penelope Papasavva-Stylianou, Marion Mathieson Simmons, Angel Ortiz-Pelaez, Otto Windl, John Spiropoulos, Soteria Georgiadou
  • Virus-Cell Interactions
    The K186E Amino Acid Substitution in the Canine Influenza Virus H3N8 NS1 Protein Restores Its Ability To Inhibit Host Gene Expression
    Aitor Nogales, Caroline Chauché, Marta L. DeDiego, David J. Topham, Colin R. Parrish, Pablo R. Murcia, Luis Martínez-Sobrido
  • Free
    Virus-Cell Interactions
    A Polymorphism within the Internal Fusion Loop of the Ebola Virus Glycoprotein Modulates Host Cell Entry
    Markus Hoffmann, Lisa Crone, Erik Dietzel, Jennifer Paijo, Mariana González-Hernández, Inga Nehlmeier, Ulrich Kalinke, Stephan Becker, Stefan Pöhlmann
  • Virus-Cell Interactions
    Virulence-Associated Substitution D222G in the Hemagglutinin of 2009 Pandemic Influenza A(H1N1) Virus Affects Receptor Binding
    Salin Chutinimitkul, Sander Herfst, John Steel, Anice C. Lowen, Jianqiang Ye, Debby van Riel, Eefje J. A. Schrauwen, Theo M. Bestebroer, Björn Koel, David F. Burke, Kyle H. Sutherland-Cash, Chris S. Whittleston, Colin A. Russell, David J. Wales, Derek J. Smith, Marcel Jonges, Adam Meijer, Marion Koopmans, Guus F. Rimmelzwaan, Thijs Kuiken, Albert D. M. E. Osterhaus, Adolfo García-Sastre, Daniel R. Perez, Ron A. M. Fouchier
  • Virus-Cell Interactions
    Mutagenesis of Adeno-Associated Virus Type 2 Capsid Protein VP1 Uncovers New Roles for Basic Amino Acids in Trafficking and Cell-Specific Transduction
    Jarrod S. Johnson, Chengwen Li, Nina DiPrimio, Marc S. Weinberg, Thomas J. McCown, R. Jude Samulski
  • Free
    Pathogenesis and Immunity
    Introduction of Virulence Markers in PB2 of Pandemic Swine-Origin Influenza Virus Does Not Result in Enhanced Virulence or Transmission
    Sander Herfst, Salin Chutinimitkul, Jianqiang Ye, Emmie de Wit, Vincent J. Munster, Eefje J. A. Schrauwen, Theo M. Bestebroer, Marcel Jonges, Adam Meijer, Marion Koopmans, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus, Daniel R. Perez, Ron A. M. Fouchier
  • Virus-Cell Interactions
    A Single Amino Acid Substitution in the Capsid of Foot-and-Mouth Disease Virus Can Increase Acid Lability and Confer Resistance to Acid-Dependent Uncoating Inhibition
    Miguel A. Martín-Acebes, Verónica Rincón, Rosario Armas-Portela, Mauricio G. Mateu, Francisco Sobrino

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