alphaherpesvirus
Pathogenesis and ImmunityCRISPR/Cas9-Constructed Pseudorabies Virus Mutants Reveal the Importance of UL13 in Alphaherpesvirus Escape from Genome SilencingAlphaherpesviruses have mastered various strategies to persist in an immunocompetent host, including the induction of latency and reactivation in peripheral nervous system (PNS) ganglia. We recently discovered that the molecular mechanism underlying escape from latency by the alphaherpesvirus pseudorabies virus (PRV) relies on a structural viral tegument protein.
Pathogenesis and ImmunityMarek’s Disease Virus Requires Both Copies of the Inverted Repeat Regions for Efficient In Vivo Replication and PathogenesisMarek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that infects chickens and causes losses in the poultry industry of up to $2 billion per year. The virus is also widely used as a model to study alphaherpesvirus pathogenesis and virus-induced tumor development in a natural host. MDV and most other herpesviruses harbor direct or inverted repeats regions in their genome. However, the role of these sequence duplications in...
Virus-Cell Interactions | SpotlightPseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1APseudorabies virus (PRV) is an alphaherpesvirus related to human pathogens herpes simplex viruses 1 and 2 and varicella-zoster virus. Alphaherpesviruses are neuroinvasive pathogens that establish lifelong latent infections in the host peripheral nervous system (PNS). Following reactivation from latency, infection spreads from the PNS back via axons to the peripheral mucosal tissues, a process mediated by kinesin motors. Here, we unveil...
Pathogenesis and Immunity | SpotlightAn Alphaherpesvirus Exploits Antimicrobial β-Defensins To Initiate Respiratory Tract InfectionHow herpesviruses circumvent mucosal defenses to promote infection of new hosts through the respiratory tract remains unknown due to a lack of host-specific model systems. We used the alphaherpesvirus equine herpesvirus type 1 (EHV1) and equine respiratory tissues to decipher this key event in general alphaherpesvirus pathogenesis. In contrast to several respiratory viruses and bacteria, EHV1 resisted potent antimicrobial equine β-...
- Virus-Cell Interactions | SpotlightStructure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops