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3Dpol

  • Residues within the Foot-and-Mouth Disease Virus 3D<sup>pol</sup> Nuclear Localization Signal Affect Polymerase Fidelity
    Virus-Cell Interactions
    Residues within the Foot-and-Mouth Disease Virus 3Dpol Nuclear Localization Signal Affect Polymerase Fidelity

    In this study, we employed genetic and molecular dynamics approaches to analyze the role of individual amino acids of the FMDV 3Dpol nuclear localization signal (NLS). The NLS residues were mutated to alanine using a type A full-genome cDNA clone, and the virus progeny was analyzed for defects in growth and in competition with the parental virus. We identified two mutants in 3Dpol, T19A and L21A, that exhibited...

    Anna Kloc, Devendra K. Rai, Douglas P. Gladue, Elizabeth Schafer, Mary Kenney, Elizabeth Rieder
  • Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5′ Untranslated Region
    Virus-Cell Interactions
    Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5′ Untranslated Region

    Picornaviruses, as a large family of human and animal pathogens, cause a bewildering array of disease syndromes. Many host factors are implicated in the pathogenesis of these viruses, and some proteins interact with the viral IRES elements to affect function. Here, we report for the first time that cellular hnRNP L specifically interacts with the IRES of the picornavirus FMDV and negatively regulates FMDV replication through inhibiting...

    Chao Sun, Mengmeng Liu, Jitao Chang, Decheng Yang, Bo Zhao, Haiwei Wang, Guohui Zhou, Changjiang Weng, Li Yu
  • Structure and Assembly
    Crystal Structure and Thermostability Characterization of Enterovirus D68 3Dpol
    Chunnian Wang, Caiyan Wang, Qing Li, Zhong Wang, Wei Xie
  • Genome Replication and Regulation of Viral Gene Expression
    Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity
    Devendra K. Rai, Fayna Diaz-San Segundo, Grace Campagnola, Anna Keith, Elizabeth A. Schafer, Anna Kloc, Teresa de los Santos, Olve Peersen, Elizabeth Rieder
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