3Dpol
Virus-Cell InteractionsResidues within the Foot-and-Mouth Disease Virus 3Dpol Nuclear Localization Signal Affect Polymerase FidelityIn this study, we employed genetic and molecular dynamics approaches to analyze the role of individual amino acids of the FMDV 3Dpol nuclear localization signal (NLS). The NLS residues were mutated to alanine using a type A full-genome cDNA clone, and the virus progeny was analyzed for defects in growth and in competition with the parental virus. We identified two mutants in 3Dpol, T19A and L21A, that exhibited...
Virus-Cell InteractionsHeterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5′ Untranslated RegionPicornaviruses, as a large family of human and animal pathogens, cause a bewildering array of disease syndromes. Many host factors are implicated in the pathogenesis of these viruses, and some proteins interact with the viral IRES elements to affect function. Here, we report for the first time that cellular hnRNP L specifically interacts with the IRES of the picornavirus FMDV and negatively regulates FMDV replication through inhibiting...
- Structure and AssemblyCrystal Structure and Thermostability Characterization of Enterovirus D68 3Dpol
- Genome Replication and Regulation of Viral Gene ExpressionAttenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity